https://scholars.lib.ntu.edu.tw/handle/123456789/194909
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 小兒科 | en |
dc.contributor.author | CHIANG, BOR-LUEN | en |
dc.contributor.author | HSU, KWAN-LIH | en |
dc.contributor.author | HUANG, ZEI-SHUNG | en |
dc.creator | 江伯倫;許寬立;黃瑞雄 | zh-tw |
dc.creator | CHIANG, BOR-LUEN;HSU, KWAN-LIH;HUANG, ZEI-SHUNG | en |
dc.date | 2000 | en |
dc.date.accessioned | 2008-12-29T06:07:38Z | - |
dc.date.accessioned | 2018-07-11T17:54:26Z | - |
dc.date.available | 2008-12-29T06:07:38Z | - |
dc.date.available | 2018-07-11T17:54:26Z | - |
dc.date.issued | 2000 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/94801 | - |
dc.description.abstract | Background: The serum level of soluble tumor necrosis factor receptor II (sTNF-R75) has been recently found to correlate with the activity and/or severity of several different infectious and inflammatory diseases. These results have led us to presume that the serum sTNF-R75 level reflects the active immune activity of all causes and may correlate well with nonspecific infectious and inflammatory markers such as peripheral leukocyte counts and serum C-reactive protein level. Methods: In total, 110 apparently healthy adults, 55 men and 55 women, were enrolled in the study. Serum levels of sTNF-R75, C-reactive protein, globulin, alkaline phosphatase, lactate dehydrogenase, creatinine, urea nitrogen, and counts of neutrophils, lymphocytes, monocytes, eosinophils, and basophils were checked. The relationships between the serum sTNF-R75 level and other parameters were analyzed using the SAS statistical program. Results: By various statistical methods, the serum sTNF-R75 level showed consistently significant positive links with peripheral monocyte count, serum C- reactive protein level, and two parameters of renal clearance function ( serum urea nitrogen and creatinine levels). Serum levels of alkaline phosphatase and lactate dehydrogenase had significant positive links with the serum sTNF-R75 level by multivariate regression analysis. There was no significant link between the serum sTNF-R75 level and counts of neutrophils, lymphocytes, eosinophils, or basophils. Conclusions: Our results, together with those of recent reports showing positive correlations between the serum sTNF-R75 level and activities /severities of different infectious and inflammatory diseases, and also that TNF-alpha is principally produced by monocytes and macrophages, suggest that the serum sTNF-R75 level is very probably an index of overall monocyte-related infectious and inflammatory activities. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | AMERICAN JOURNAL OF THE MEDICAL SCIENCES v.320 n.3 pp.183-187 | en |
dc.relation.ispartof | AMERICAN JOURNAL OF THE MEDICAL SCIENCES | - |
dc.subject | receptors | en |
dc.subject | tumor necrosis factor | en |
dc.subject | C-reactive protein | en |
dc.subject | monocytes | en |
dc.subject | inflammation infection | en |
dc.title | Serum Level of Soluble Tumor Necrosis Factor Receptor Ii (Stnf-R75) Is Apparently an Index of Overall Monocyte-Related Infectious and Inflammatory Activity | en |
dc.type | journal article | en |
dc.relation.pages | 183-187 | - |
dc.relation.journalvolume | v.320 | - |
dc.relation.journalissue | n.3 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en_US | - |
item.cerifentitytype | Publications | - |
顯示於: | 醫學系 |
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