https://scholars.lib.ntu.edu.tw/handle/123456789/194919
標題: | Fluconazole Therapy in Neonatal Candidemia | 作者: | Huang, Yhu-Chering Lin, Tzou-Yien Lien, Rey-In Chou, Yi-Hong Kuo, Chii-Yuh Yang, Peng-Hong Hsieh, Wu-Shiun |
關鍵字: | fluconazole;neonate;candidemia;INTENSIVE-CARE UNIT;AMPHOTERICIN-B;RANDOMIZED TRIAL | 公開日期: | 2000 | 卷: | v.17 | 期: | n.8 | 起(迄)頁: | 411-415 | 來源出版物: | AMERICAN JOURNAL OF PERINATOLOGY | 摘要: | We reviewed 62 episodes (from 59 infants) of neonatal candidemia that occurred between January 1994 and June 1999. Except 5 term babies, all infants were premature (median gestational age [GA], 30 weeks) and birth weight was less than 2500 g (median, 1300 g). Most infants had reported risk factors and other neonatal problems. The age at onset of candidemia ranged from 15 to 173 days with a median of 34 days. In addition to catheter removal, all but one infants received antifungal agents and candidemia was eradicated subsequently in 46 episodes (75%). Eighteen infants with 19 episodes ever received fluconazole therapy. Fluconazole was administered as the first line agent in 6 episodes and successfully cleared candidemia in 5 episodes. Fluconazole was used as an alternative agent in an additional 13 episodes after amphotericin B (am B) +/- flucytosine were given for a period without a satisfactory result and eradication of candidemia was achieved in 8 episodes subsequently. All 18 infants tolerated fluconazole well and no withdrawal was required on account of its adverse effect. In contrast, am B alone was administered as the first line agent in 55 episodes and successfully cleared candidemia in 32 episodes (58%). This retrospective analysis suggests that fluconazole appears to be safe in neonates and can be used as an alternative agent in treating neonatal candidemia. A large-scaled prospective study may be needed. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/94811 |
顯示於: | 醫學系 |
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