|Title:||Systemic Immunity-Enhancing Effects in Healthy Subjects Following Dietary Consumption of the Lactic Acid Bacterium Lactobacillus Rhamnosus Hn001||Authors:||CHIANG, BOR-LUEN||Keywords:||Lactobacillus;rhamnosus immune enhancement;phagocytosis;NK cells;ELDERLY SUBJECTS;NHANCEMENT||Issue Date:||2001||Journal Volume:||v.20||Journal Issue:||n.2||Start page/Pages:||149-156||Source:||JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION||Abstract:||
Objective: To determine the effects of the probiotic lactic acid bacterium, Lactobacillus rhamnosus HN001, on natural cellular immunity when delivered orally in normal low-fat milk (LFM) or lactose-hydrolized low-fat milk (LFM-LH). Design: A three stage, pre-post intervention trial, spanning nine weeks.Setting: Taipei Medical College Hospital, Taipei , Taiwan.Subjects: Fifty-two healthy middle-aged and elderly volunteers (17 males, 35 females; median age 63.5, range 44 -80).Interventions: Stage 1 ( run-in diet): 25g/200 mL reconstituted LFM powder, twice daily for 3 weeks . Stage 2 ( probiotic intervention): LFM or LFM-LH, supplemented with 10(9 ) CFUs/g L. rhamnosus HN001 in each case, for 3 weeks. Stage 3 (wash-out): LFM for 3 weeks.Measures of Outcome: In vitro phagocytic capacity of peripheral blood polymorphonuclear (PMN) leukocytes; in vitro tumoricidal activity of natural killer (NK) leukocytes.Results: Immunological responses were unaffected by the run-in diet of LFM alone. In contrast, the relative proportion of PMN cells showing phagocytic activity increased by 19% and 15%, respectively, following consumption of HN001 in either LFM or LFM-LH; the relative level of NK cell tumor killing activity increased by 71% and 147%. In most cases these levels declined following cessation, but remained above baseline.Conclusion: Dietary consumption of L. rhamnosus HN 001, in a base of low-fat milk or lactose-hydrolyzed low- fat milk, appears to enhance systemic cellular immune responses and may be useful as a dietary supplement to boost natural immunity.
|Appears in Collections:||醫學系|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.