https://scholars.lib.ntu.edu.tw/handle/123456789/194947
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 小兒科 | en |
dc.contributor.author | CHIANG, BOR-LUEN | en |
dc.creator | 江伯倫 | zh-tw |
dc.creator | CHIANG, BOR-LUEN | en |
dc.date | 2002 | en |
dc.date.accessioned | 2008-12-29T06:13:21Z | - |
dc.date.accessioned | 2018-07-11T17:55:26Z | - |
dc.date.available | 2008-12-29T06:13:21Z | - |
dc.date.available | 2018-07-11T17:55:26Z | - |
dc.date.issued | 2002 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/94839 | - |
dc.description.abstract | The mechanisms that cause the inflammation of airway and lung tissue in asthma have been studied extensively. It is noted that type 1 T helper cell (Th1)-related cytokines could decrease the accumulation of eosinophils in lung tissue and relieve airway constriction. But the therapeutic mechanisms of Th1 cytokines remain unclear. In this study, interleukin-12 (IL-12) DNA plasmid as a therapeutic reagent was delivered intravenously. Bronchoalveolar lavage (BAL) fluids were collected from IL- 12 treated and control mice, and analyzed for cell composition and eotaxin level. The results showed that IL-12 DNA plasmid could effectively inhibit eosinophilia and airway inflammation in vivo. The level of eotaxin in BAL fluid also decreased. To further investigate the effect of Th1- related cytokines, such as IL- 12 or interferon-gamma (IFN-gamma) on the eotaxin level produced by lung cells, primary lung cell culture was established. The results demonstrated that both IL-12 and IFN-gamma could suppress eotaxin secretion from IL-13 or IL- 4 stimulated primary lung cell culture. Moreover, the inhibitory effect of IL-12 could not be reversed by the administration of anti-IFN-gamma antibody. All the evidences suggested that IL-12 could regulate airway inflammation by suppressing the eotaxin secretion of lung tissue through an IFN-gamma independent mechanism. (C) 2002 Elsevier Science Ltd. All rights reserved. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | CYTOKINE v.19 n.2 pp.76-84 | en |
dc.relation.ispartof | CYTOKINE | - |
dc.subject | eotaxin | en |
dc.subject | interferon-gamma | en |
dc.subject | interleukin-12 | en |
dc.subject | lung cell culture | en |
dc.title | Interleukin-12 Inhibits Eotaxin Secretion of Cultured Primary Lung Cells and Alleviates Airway Inflammation in Vivo | en |
dc.type | journal article | en |
dc.relation.pages | 76-84 | - |
dc.relation.journalvolume | v.19 | - |
dc.relation.journalissue | n.2 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
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