|Title:||Antibiotic Usage in Community-Acquired Infections in Hospitals in Taiwan||Authors:||HO, MON-TO
|Keywords:||in-hospital infections;pneumonias;appropriate antibiotics;RESISTANT STREPTOCOCCUS-PNEUMONIAE;PENICILLIN-RESISTANT;HIGH PREVALENCE||Issue Date:||2002||Journal Volume:||v.101||Journal Issue:||n.1||Start page/Pages:||34-42||Source:||JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION||Abstract:||
Background and Purpose: Using an epidemiologically meaningful in-hospital population with community-acquired infections, we evaluated antibiotic therapy In terms of indication and choice of antibiotic and microbiologic work- up. Methods:. Infectious disease specialists evaluated charts of 436 patients from 9 hospitals and selected those who received antibiotics within 3 days of admission, Each antibiotic prescribed was marked for appropriateness, of indication and choice. Microbiologic isolates were evaluated for their clinical significance. Results: The most common infections were in the lower respiratory tract (46.1%). Each patient received a mean of 2.25 antibiotics for 8.1 +/- 6.4 days. Of the 975 courses Of antibiotics given in the study period. indication and choice were correct in 37.4% and unsatisfactory in 14.5%. The vast majority Of antibiotics used (79.2%) were first-line antibiotics - usually first- generation cephalosporins aminoglycosides, and aminopenicillins. Most patients (66%) had a microbiology, laboratory work-Up, but Only 37.4Y were judged by evaluators to have a meaningful microbiologic diagnosis. Among the 201 patients With lower respiratory tract infections, 105 (52.2 %) had a diagnosis Of pneumonia. A positive isolate was recovered in 30 (28.6%) patients, and most of these isolates (20.68.7%) were aerobic gram-negative rods. There were three positive blood cultures but none grew Streptococcus pneumoniae. Conclusions: Antibiotics, were used excessively in number and duration. The microbiologic work-Up had little effect on the indication and choice of antibiotics. Community-acquired pneumoniae differed markedly, from that in Western countries in that only 3.3% were caused by S. pneumoniae.
|Appears in Collections:||醫學系|
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