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  4. Sudden Death in Patients with Right Isomerism (Asplenism) after Palliation
 
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Sudden Death in Patients with Right Isomerism (Asplenism) after Palliation

Resource
JOURNAL OF PEDIATRICS v.140 n.1 pp.93-96
Journal
JOURNAL OF PEDIATRICS
Journal Volume
v.140
Journal Issue
n.1
Pages
93-96
Date Issued
2002
Date
2002
Author(s)
WU, MEI-HWAN
WANG, JOU-KOU
URI
http://ntur.lib.ntu.edu.tw//handle/246246/94841
Abstract
Objective: To define the risk of sudden death in patients with right isomerism (asplenia) after palliation Study design: A total of 154 patients with right isomerism was identified from 1980 to 1999. Sudden death was defined as acute cardiovascular collapse from which death occurred within 24 hours. Results: A total of 620 patient-years were evaluated. The 1-year and 5-year survival was 72% and 50%, respectively. There were 22 sudden unexpected deaths (14%, 35 events/1000 patient-years) . Sudden death tended to occur in infancy or early childhood (12 +/- 9 months; median, 9 months). The mechanisms were classified as sudden tachyarrhythmic in 2 (9%), sudden cardiac but nontachyarrrhythmic (sudden onset severe cyanosis) in 15 (68 %), and sudden noncardiac in 5 (23%)( fulminant sepsis with positive blood culture: streptococcus pneumonia (3), Fsebericia coli (1), and yeast-like organism (1)). The incidence of sudden death steadily decreased with age until the age of 3 years. Conclusion: The incidence of sudden death in patients with right isomerism after initial palliation remained high. Sudden death was related to complex cardiac anomalies, a susceptibility to fulminant infection, and arrhythmia.
Subjects
RIGHT ATRIAL ISOMERISM
MALFORMATIONS
OPERATION
DIAGNOSIS
CHILDREN
INFANCY
Type
journal article

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