|Title:||Long-Term Immunogenicity and Efficacy of Universal Hepatitis B Virus Vaccination in Taiwan||Authors:||LIN, YU-CHEN
|Keywords:||ANTIGEN CARRIER MOTHERS;SURFACE-ANTIGEN;CORE ANTIGEN;INFECTION;CHILDREN;INFANTS||Issue Date:||2003||Journal Volume:||v.187||Journal Issue:||n.1||Start page/Pages:||134-138||Source:||JOURNAL OF INFECTIOUS DISEASES||Abstract:||
The long-term immunogenicity of universal hepatitis B virus( HBV) vaccine is seldom studied in large-scale prospective community-based populations, especially in adolescents. This study enrolled 1200 children aged 7 years with complete HBV immunization in infancy and determined HBV surface antigen( HBsAg), its antibody (anti-HBs), and HBV core antibody ( anti-HBc ) annually until the children were aged 14 years. Eleven children had new HBV infections with anti-HBc positivity as the only marker. None became positive for HBsAg or had detectable HBV DNA by polymerase chain reaction . The percentage of protective anti-HBs in 951 children without booster vaccination gradually decreased from 71.1% at age 7 years to 37.4% at age 12 years. Only 1 of the 200 children in the booster group and 2 of the 258 children in the nonbooster group developed new anti-HBc positivity. The results suggest that routine booster vaccination may not be required to provide protection against chronic HBV infection before age 15 years.
|Appears in Collections:||醫學系|
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