Long-Term Immunogenicity and Efficacy of Universal Hepatitis B Virus Vaccination in Taiwan
Resource
JOURNAL OF INFECTIOUS DISEASES v.187 n.1 pp.134-138
Journal
JOURNAL OF INFECTIOUS DISEASES
Journal Volume
v.187
Journal Issue
n.1
Pages
134-138
Date Issued
2003
Date
2003
Author(s)
LIN, YU-CHEN
CHANG, MEI-HWEI
NI, YEN-HSUAN
HSU, HONG-YUAN
CHEN, DING-SHINN
Abstract
The long-term immunogenicity of universal hepatitis B virus( HBV) vaccine is seldom studied in large-scale prospective community-based populations, especially in adolescents. This study enrolled 1200 children aged 7 years with complete HBV immunization in infancy and determined HBV surface antigen( HBsAg), its antibody (anti-HBs), and HBV core antibody ( anti-HBc ) annually until the children were aged 14 years. Eleven children had new HBV infections with anti-HBc positivity as the only marker. None became positive for HBsAg or had detectable HBV DNA by polymerase chain reaction . The percentage of protective anti-HBs in 951 children without booster vaccination gradually decreased from 71.1% at age 7 years to 37.4% at age 12 years. Only 1 of the 200 children in the booster group and 2 of the 258 children in the nonbooster group developed new anti-HBc positivity. The results suggest that routine booster vaccination may not be required to provide protection against chronic HBV infection before age 15 years.
Subjects
ANTIGEN CARRIER MOTHERS
SURFACE-ANTIGEN
CORE ANTIGEN
INFECTION
CHILDREN
INFANTS
SDGs
Type
journal article