https://scholars.lib.ntu.edu.tw/handle/123456789/194965
Title: | Long-Term Immunogenicity and Efficacy of Universal Hepatitis B Virus Vaccination in Taiwan | Authors: | LIN, YU-CHEN CHANG, MEI-HWEI NI, YEN-HSUAN HSU, HONG-YUAN CHEN, DING-SHINN |
Keywords: | ANTIGEN CARRIER MOTHERS;SURFACE-ANTIGEN;CORE ANTIGEN;INFECTION;CHILDREN;INFANTS | Issue Date: | 2003 | Journal Volume: | v.187 | Journal Issue: | n.1 | Start page/Pages: | 134-138 | Source: | JOURNAL OF INFECTIOUS DISEASES | Abstract: | The long-term immunogenicity of universal hepatitis B virus( HBV) vaccine is seldom studied in large-scale prospective community-based populations, especially in adolescents. This study enrolled 1200 children aged 7 years with complete HBV immunization in infancy and determined HBV surface antigen( HBsAg), its antibody (anti-HBs), and HBV core antibody ( anti-HBc ) annually until the children were aged 14 years. Eleven children had new HBV infections with anti-HBc positivity as the only marker. None became positive for HBsAg or had detectable HBV DNA by polymerase chain reaction . The percentage of protective anti-HBs in 951 children without booster vaccination gradually decreased from 71.1% at age 7 years to 37.4% at age 12 years. Only 1 of the 200 children in the booster group and 2 of the 258 children in the nonbooster group developed new anti-HBc positivity. The results suggest that routine booster vaccination may not be required to provide protection against chronic HBV infection before age 15 years. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/94857 |
Appears in Collections: | 醫學系 |
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