|Title:||Oral Clodronate Therapy for Hypercalcemia Related to Extensive Subcutaneous Fat Necrosis in a Newborn||Authors:||HUNG, SHUO-HSUN
TSAO, PO- NIEN
|Keywords:||Case report;Clodronic acid;Fat necrosis;Hypercalcemia;Infant;newborn||Issue Date:||2003||Journal Volume:||v.102||Journal Issue:||n.11||Start page/Pages:||801-804||Source:||JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION||Abstract:||
Hypercalcemia is occasionally found in newborns with subcutaneous fat necrosis and carries potential life- threatening risk. Bisphosphonates have been recently introduced in the treatment of subcutaneous fat necrosis in newborns. We report a case of extensive subcutaneous fat necrosis in a female infant complicated with intractable hypercalcemia. Standard treatment for hypercalcemia was given, including saline hydration , a low calcium diet, furosemide, and glucocorticoid, but without response . Serum 1,25-dihydroxyvitamin D level was elevated at 126 pg/mL, 25- hydroxyvitamin D level was normal, and intact parathyroid hormone was suppressed at <1 pg/mL. Orla clodronate disodium , a second-generation bisphosphonate, was administered, and resulted in the normalization of serum calciu, urine N- telopeptide, urine calcium/creatminine ratio,, and serum intact parathyroid hormone level. This case suggests that oral clodronate may be an effective treatment for subcutaneous fat necrosis with hypercalcemia in newborns.
|Appears in Collections:||醫學系|
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