https://scholars.lib.ntu.edu.tw/handle/123456789/194978
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 小兒科 | en |
dc.contributor.author | CHEN, JIMMY PENG-SHENG | en |
dc.contributor.author | LIN, KAI-HSIN | en |
dc.contributor.author | TSAI, WEN-YU | en |
dc.contributor.author | WANG, SHIH-CHUNG | en |
dc.contributor.author | LU, MENG-YAO | en |
dc.contributor.author | LIN, DONG-TSAMN | en |
dc.contributor.author | LIN, KUO-SIN | en |
dc.contributor.author | LO, SU-HEUY | en |
dc.creator | 陳鵬升;林凱信;蔡文友;王士忠;盧孟佑;林東燦;林國信;羅世慧 | zh_TW |
dc.creator | CHEN, JIMMY PENG-SHENG;LIN, KAI-HSIN;TSAI, WEN-YU;WANG, SHIH-CHUNG;LU, MENG-YAO;LIN, DONG-TSAMN;LIN, KUO-SIN;LO, SU-HEUY | en |
dc.date | 2003 | en |
dc.date.accessioned | 2008-12-29T06:18:20Z | - |
dc.date.accessioned | 2018-07-11T17:55:33Z | - |
dc.date.available | 2008-12-29T06:18:20Z | - |
dc.date.available | 2018-07-11T17:55:33Z | - |
dc.date.issued | 2003 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/94870 | - |
dc.description.abstract | Objective: To determine the prevalence and risk factors of hypogonadotropic hypogonadism in transfusion-dependent patients with thalassemia. Patients and Methods: The authors examined 29 patients with thalassemia major aged 15 years or older. Luteinizing hormone-releasing hormone tests were performed and β- thalassemia mutations were analyzed by direct sequencing. Results: The prevalence of hypogonadotropic hypogonadism was 72%. Failure of puberty was observed in 5 of 11 (45%) boys and 7 of 18 (39%) girls. Arrested puberty was noted in two boys (18%) and five girls( 28%). Ten girls (56%) did not menstruate, two (11%) had regular menstrual cycles, one (6%) had irregular menstrual cycles, and five (28%) developed secondary amenorrhea. Twenty-one and eight patients had theβ0/β0 and β0/β+ hematologic phenotypes, respectively β0- thalassemia mutation alleles involved IVS II-654 (C-T), codons 41/42 (- TCTT), codons 27/28 (+C), and codons 17 (A-T). β+- thalassemia mutations alleles were -28 (A-G) and HbE ( codons 26 (GAG-AAG)). Hematologic phenotype (odds ratio, 28. 50;P=0.002) was the only risk factor identified in the logistic regression analysis. Conclusions: In patients with thalassemia major, genetic differences may unfluence their susceptibility to hypogonadotropic hypogonadism, possibly as a result of differences in the amounts of blood transfused and/or their vulnerability to free radical damage. The hematologic phenotype is a main determinant of the severity of thalassemia major, hence, it may influence the need for and frequency of blood transfusion and the patient's iron- overload status. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | JOURNAL OF PEDIATRIC HEMATOLOGY/ONCOLOGY v.25 n.11 pp.880-884 | en |
dc.relation.ispartof | JOURNAL OF PEDIATRIC HEMATOLOGY/ONCOLOGY | - |
dc.subject | thalassemia | en |
dc.subject | hypogonadotropic hypogonadism | en |
dc.subject | hematologic genotype | en |
dc.subject | hematologic phenotype | en |
dc.title | Hypogonadotropic Hypogonadism and Hematologic Phenotype in Patients with Transfusion-Dependent Beta-Thalassemia | en |
dc.type | journal article | en |
dc.relation.pages | 880-884 | - |
dc.relation.journalvolume | v.25 | - |
dc.relation.journalissue | n.11 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
顯示於: | 醫學系 |
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