https://scholars.lib.ntu.edu.tw/handle/123456789/195002
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 小兒科 | en |
dc.contributor.author | Yang, Mei-Hui | en |
dc.contributor.author | Suen, Jau-Ling | en |
dc.contributor.author | Li, Shiao-Lan | en |
dc.contributor.author | Chiang, Bor-Luen | en |
dc.creator | 孫昭玲;江伯倫 | zh-tw |
dc.creator | Yang, Mei-Hui; Suen, Jau-Ling; Li, Shiao-Lan; Chiang, Bor-Luen | en |
dc.date | 2005 | en |
dc.date.accessioned | 2008-12-29T06:22:24Z | - |
dc.date.accessioned | 2018-07-11T17:55:38Z | - |
dc.date.available | 2008-12-29T06:22:24Z | - |
dc.date.available | 2018-07-11T17:55:38Z | - |
dc.date.issued | 2005 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/94895 | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is characterized by the existence of a heterogeneous group of autoantibodies such as anti-DNA, chromatin, histone, and ribonucleoprotein antibodies (Abs). Although the B-cell antigenic determinants have been well characterized, very limited data about the T -cell epitopes of self-antigen (Ag) have been reported. In the present study, we analysed auto-T-cell epitopes using bone marrow-derived dendritic cells (BM-DCs) pulsed with murine U1A (mU1A) protein capable of activating autoreactive T cells from unprimed MRL/lpr mice in vitro. The data suggested that there are at least four T-cell epitopes on the U1A protein, U1A3150, U1A6180, U1A201220 and U1A271287, and U1A3150 had the most significant T-cell proliferative response. In addition, the main responsive T cells are the CD4 CD8 double-negative subgroup of T cells. Furthermore, we also demonstrated that the activation of double-negative T cells is major histocompatibility complex class II restricted. The study here provides information on T-cell epitope analysis of the U1A antigen using BM-DCs as the effective antigen-presenting cells. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | IMMUNOLOGY v.115 n.2 pp.279-286 | en |
dc.relation.ispartof | IMMUNOLOGY | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | en |
dc.subject | DENDRITIC CELLS | en |
dc.subject | LPR MICE | en |
dc.subject | IN- VIVO | en |
dc.subject | AUTOANTIBODIES | en |
dc.subject | AUTOIMMUNITY | en |
dc.title | Identification of T-Cell Epitopes on U1a Protein in Mrl/Lpr Mice: Double- Negative T Cells Are the Major Responsive Cells | en |
dc.type | journal article | en |
dc.relation.pages | 279-286 | - |
dc.relation.journalvolume | v.115 | - |
dc.relation.journalissue | n.2 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
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