|Title:||Urinary Epidermal Growth Factor Excretion in Children with Chronic Renal Failure||Authors:||TSAU, YONG-KWEI
|Keywords:||epidermal growth factor;chronic renal failure;lupus nephritis;creatinine clearance||Issue Date:||1999||Journal Volume:||v.19||Journal Issue:||n.3||Start page/Pages:||400-404||Source:||AMERICAN JOURNAL OF NEPHROLOGY||Abstract:||
To investigate the excretion of urinary epidermal growth factor (EGF) in children with chronic renal failure (CRF), we have measured the urinary EGF/creatinine ratio (EGF/Cr) and the 24-hour urine EGF concentration in 19 children with CRF, 11 children with kidney disease and normal creatinine clearance, and 12 healthy children. Children with CRF had a significantly lower daily urine EGF concentration as well as urinary EGF/ Cr. In contrast, children with kidney disease and normal renal function had normal daily urine EGF levels and urinary EGF/Cr. Accompanied by no difference in serum EGF between these two groups of patients, these data provide indirect evidence of the kidney as a source of human urinary EGF. There was a positive correlation of urinary EGF /Cr with creatinine clearance in all renal patients (r = 0. 608, n = 30, p < 0.001). A much better correlation was found between daily urine EGF and creatinine clearance (r = 0.855 , n = 30, p < 0.001). Our results implicate that there is a functional relationship between glomerular filtration and urinary EGF excretion, and that the urinary EGF/Cr may be a reliable indicator of urinary EGF excretion in children with CRF.
|Appears in Collections:||醫學系|
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