https://scholars.lib.ntu.edu.tw/handle/123456789/195583
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 小兒科 | en |
dc.contributor.author | CHEN, WU-CHARNG | en |
dc.contributor.author | CHIANG, BOR-LUEN | en |
dc.contributor.author | LIU, HSING-JIN EUGENE | en |
dc.contributor.author | LEU, SY-JYE | en |
dc.contributor.author | LEE, YUEH-LUN | en |
dc.creator | 陳五常;江伯倫;劉興璟;呂思潔;李岳倫 | zh-tw |
dc.creator | CHEN, WU-CHARNG;CHIANG, BOR-LUEN;LIU, HSING-JIN EUGENE;LEU, SY-JYE;LEE, YUEH-LUN | en |
dc.date | 2008 | en |
dc.date.accessioned | 2010-06-29T02:30:40Z | - |
dc.date.accessioned | 2018-07-11T18:02:41Z | - |
dc.date.available | 2010-06-29T02:30:40Z | - |
dc.date.available | 2018-07-11T18:02:41Z | - |
dc.date.issued | 2008 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/186763 | - |
dc.description.abstract | BACKGROUND: Patients with chronic ordinary urticaria (CU) are divided into two groups: 30-50% have chronic autoimmune urticaria, and the remainder have chronic idiopathic urticaria. CD4(+)CD25(+) regulatory T ( Treg) cells play critical roles in maintaining peripheral tolerance and preventing autoimmunity, but the characteristics of Treg cells have not yet been defined in CU. OBJECTIVE: To identify whether CD4(+) T cells play an important immunoregulatory role in the etiology of CU, we determined the frequencies and functions of circulating CD4(+)CD25(+) and CD4(+)CD25( -) T cells in CU patients and healthy control subjects, with special focus on the characteristics of CD4( +)CD25(+) T cells. METHODS: Peripheral blood mononuclear cells (PBMCs) were obtained from CU and healthy controls in this study. The frequency of CD4(+)CD25(+) T cells in PBMCs was detected by flow cytometry. The expression levels of forkhead box P3 (FOXP 3) and transforming growth factor-beta( TGF-beta) in CD4(+)CD25(+) T cells were detected by real- time PCR. Furthermore, the suppressive function of CD4(+)CD 25(+) T cells was analyzed. Additionally, the Th1/Th2 cytokine secretory profile in mitogen-stimulated CD4(+)CD25( -) T cells was measured by ELISA. RESULTS: An increased frequency of CD4(+)CD25(+) T cells was observed in CU patients (n=19) compared to control subjects (n=7 ). No significant difference was detected in the expression levels of FOXP 3 or TGF-beta between CU patients (n=14) and control subjects (n=7). Strikingly, the suppressive capacity of CD4 (+)CD25(+) Treg cells from 2 of 5 CU patients was partially defective. We also found that cytokine production from CD4(+ )CD25(-) T cells was significantly reduced in CU patients (n =9) compared to healthy donors (n=11). CONCLUSIONS: Our data demonstrate that CD4(+)CD25(+) and CD4(+)CD25(-) T cells in PBMCs exhibit defective functions in CU patients. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | JOURNAL OF DERMATOLOGICAL SCIENCE v.51 n.2 pp.121-130 | en |
dc.relation.ispartof | JOURNAL OF DERMATOLOGICAL SCIENCE | - |
dc.subject | chronic ordinary urticaria | en |
dc.subject | CD4+CD25+ regulatory T cells | en |
dc.subject | FOXP3 | en |
dc.subject | suppressive function | en |
dc.subject | CD4+CD25- T cells | en |
dc.subject | cytokines | en |
dc.title | Defective Functions of Circulating Cd4+Cd25+ and Cd4+Cd25- T Cells in Patients with Chronic Ordinary Urticaria | en |
dc.type | journal article | en |
dc.relation.pages | 121-130 | - |
dc.relation.journalvolume | v.51 | - |
dc.relation.journalissue | n.2 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
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