|Title:||Hormonal and Body-Size Factors in Relation to Breast Cancer Risk: A Prospective Study of 11,889 Women in a Low-Incidence Area||Authors:||WU, MEI-HSUAN
YU, JYH- CHERNG
|Keywords:||body size;breast cancer;hormonal risk factors;prospective study||Issue Date:||2006||Journal Volume:||v.16||Journal Issue:||n.3||Start page/Pages:||223-229||Source:||ANNALS OF EPIDEMIOLOGY||Abstract:||
PURPOSE: This prospective cohort study of 11,889 women was conducted to determine significant factors associated with the risk of breast cancer among Chinese women in Taiwan, a low-incidence area. METHODS: In-person interviews were completed for subjects to solicit information on hormonal factors. Measurements of height, weight, and waist-and-hip circumferences were performed by well-trained assistants using standardized techniques. Cox proportional hazards models were employed to estimate relative risks ( RRs) and 95 % confidence intervals (CIs). RESULTS: During an average follow-up time of 10.3 years (range: 1 to 11 years) with an accumulation of 134,063 person-years, 104 incident breast cancer cases were identified through data linkage with national cancer registry profile. There was a significant elevation in breast-cancer risk with increasing duration of the interval between age at menarche and age at first full- term pregnancy (FFTP). Additionally, central adiposity reflected by hip circumference was a significant predictor of breast cancer in this Chinese female population. CONCLUSIONS: The findings of this study indicated common mechanisms responsible for the higher incidence of breast cancer in Western populations may also explain the risk of breast cancer development in Taiwan, a low-incidence area.
|Appears in Collections:||醫學系|
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