https://scholars.lib.ntu.edu.tw/handle/123456789/197016
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 婦產科 | en |
dc.contributor.author | FERBAS JOHN | en |
dc.contributor.author | KAPLAN ANDREW H. | en |
dc.contributor.author | HAUSNER MARY ANN | en |
dc.contributor.author | HULTIN LANCE E. | en |
dc.contributor.author | MATUD JOSE L. | en |
dc.contributor.author | LIU, ZHIYUAN | en |
dc.contributor.author | PANICALI DENNIS L. | en |
dc.contributor.author | HO, HONG-NERNG | en |
dc.contributor.author | DETELS ROGER | en |
dc.contributor.author | GIORGI JANIS, V. | en |
dc.creator | 何弘能 | zh-tw |
dc.creator | FERBAS JOHN;KAPLAN ANDREW H.;HAUSNER MARY ANN;HULTIN LANCE E.;MATUD JOSE L.;LIU, ZHIYUAN;PANICALI DENNIS L.;HO, HONG-NERNG;DETELS ROGER;GIORGI JANIS, V. | en |
dc.date | 1995 | en |
dc.date.accessioned | 2009-01-19T02:20:13Z | - |
dc.date.accessioned | 2018-07-12T00:42:08Z | - |
dc.date.available | 2009-01-19T02:20:13Z | - |
dc.date.available | 2018-07-12T00:42:08Z | - |
dc.date.issued | 1995 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/99264 | - |
dc.description.abstract | Persons infected with human immunodeficincy virus (HIV) for > 8 years were studied to delinate virologic and immunologic attributes of long- term survival. Whereas those with 300-700 CD4+ cell/mL often had circulating cytotoxic T lymphocytes (CTL) agaist HIV antigens, those with > 1000 CD4+ cells/mL did not. The subjects with > 1000 CD4+ cells/mL had low virus burden, low levels of Gag-specific CTL precursors, and minimal CD8+ cell activation. Overall, elevated levels of CD8+ cells , CD38 antigen expression on CD8+ cells, and anti-HIV functions were correlated with increased virus burden, provirus load, and HIV plasma RNA levels. A factor that supressed HIV replication was spontaneously secrected from Cd8+ cells of most subjects but not from those with high CD 4+ cell counts. CD8+ cell activities, therefore, may reflect chronic viral stimulation of the immune system. Long-term survivors with high level of CD4+ cells maintained control of viral replication but lacked the CD8 + cell activation. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | JOURNAL OF INFECTIOUS DISEASES v.172 n.2 pp.329-339 | en |
dc.relation.ispartof | JOURNAL OF INFECTIOUS DISEASES | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Virus burden in long-term survivors of human immunodeficiency virus (HIV) infection is a determinant of anti-HIV CD8+ lymphocyte activity | en |
dc.relation.pages | 329-339 | - |
dc.relation.journalvolume | v.172 | - |
dc.relation.journalissue | n.2 | - |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
顯示於: | 醫學系 |
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