|Title:||The Effects of Short-Term Use of Estradiol and Norethisterone-Based Hormone Replacement Therapy in Postmenopausal Women||Authors:||CHEN, RUEY-JIEN
|Keywords:||hormone replacement therapy;climecteric;cholexterol;bone resorption||Issue Date:||2002||Journal Volume:||v.41||Journal Issue:||n.4||Start page/Pages:||131-136||Source:||TAIWANESE JOURNAL OF OBSTETRICS AND GYNECOLOGY||Abstract:||
Objective: To evaluate the immediate effect of daily combined hormone replacement therapy (estradiol 2mg/day, norethisterone acetate 1mg/day) on menopausal symptoms, blood lipid profiles, osteoporosis and uterine bleeding patterns. Methods: An open non-comparative study was conducted on thirty-six women with an intact uterus. Thirty cases were included for final analysis. Menopausal symptoms were assessed by the Kupperman index. Serum lipid profiles, sex hormone levels, liver and renal function, and urinary N- telopeptide (NTx) levels were measured before treatment and at three and six months after treatment began. Results: Daily treatment with estradiol and norethisterone was well tolerated and, without changing triglyceride levels, significantly reduced menopausal symptoms, decreased total and low-density lipoprotein cholesterol levels, and reduced bone resorption. The rate of vaginal spotting and bleeding also declined. Conclusion: Our results indicate that this regimen in a short term period may reduce menopausal symptoms, decrease cholesterol levels, and reduce bone resorption in menopausal women.
|Appears in Collections:||醫學系|
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