https://scholars.lib.ntu.edu.tw/handle/123456789/197081
標題: | Cryopreserved Sibling Oocytes and Intracytoplasmic Sperm Injection Rescue Unexpectedly Poor Fertilization in Conventional in Vitro Fertilization | 作者: | CHEN, SHEE-UAN LIEN, YIH-RON CHANG, LI- JUNG TSAI, YI-YI HO, HONG-NERNG YANG, YU-SHIH |
關鍵字: | cryopreserved oocytes;ntracytoplasmic sperm injection;unexpected fertilization failures | 公開日期: | 2004 | 卷: | v.21 | 期: | n.10 | 起(迄)頁: | 367-369 | 來源出版物: | JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 摘要: | Purpose: To report a successful pregnancy from cryopreserved sibling oocytes and intracytoplasmic sperm injection ( ICSI ) for an infertile couple with an unexpectedly low fertilization rate in the fresh in vitro fertilization (IVF) cycle. Methods: The woman had bilateral tubal obstruction and polycystic ovarian syndrome. The man had normal semen parameters. The couple underwent a cycle of controlled ovarian hyperstimulation in that 20 oocytes were retrieved. Twelve oocytes were conventionally inseminated and eight were cryopreserved using a slow freezing method. However, only one oocyte was fertilized, and no pregnancy was achieved. In the next cycle, the frozen oocytes were thawed and ICSI was performed. Results: After thawing, seven oocytes (88%) survived and one was damaged. Six were at the metaphase II stage and were injected. Five (83%) achieved normal fertilization, and all of them cleaved (100%). After replacement of the embryos, a singleton pregnancy developed. A healthy female baby was delivered at term. Karyotyping revealed 46, XX. Conclusions: In addition to well-known indications, cryopreservation of excess sibling oocytes for patients receiving IVF has a possible advantage of preventing unexpectedly low fertilization rate or fertilization failures. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/99411 |
顯示於: | 醫學系 |
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