https://scholars.lib.ntu.edu.tw/handle/123456789/197922
標題: | 行政院國家科學委員會專題研究計畫成果報告:台灣地區癲癇症臨床及流行病學研究 | 作者: | 劉宏輝 | 公開日期: | 2000 | 出版社: | 臺北市:國立臺灣大學醫學院神經科 | 摘要: | 本研究的目的在估計台灣本土點頭癲痛症之發生率、盛行率和死亡率;同時嘗試找出該症相關危險因子。從一家醫學中心找出所有被診斷為癲痛症的病患共12694 個,再從此族群找出1985 至1997 年被確診為點頭癲痛症的69 個病息作為一回溯性研究世代。利用點頭癲痛症回溯性研究世代和台灣全民健保資料及全國死亡檔估計發生率、盛行率和死亡率。利用醫院病例對照研究法探討相關危險因子。69 個點頭癲痛症病,t .中僅25 位完成電訪問卷調查。從同一個醫學中心其他疾病類別隨機抽樣得106 個有病的人組成「疾病對照組」。另外從同一時期在該醫學中心出生的小孩隨機抽樣得139 個人組成「正常對照組」。利用迥歸分析估算危險對比值和95 %信賴區間。該醫學中心點頭癲痛症發生率估計為每一千活產數約0 . 06 人;0 到9 歲點頭癲痴症盛行率為每一千人約0 , 05 • 點頭癲痛症的死亡率比疾病對照組約高兩倍。危險因子包括結節性硬化症、腦性麻痺和除中樞神經系統外其他先天性畸形;週產期危險因子包括新生兒窒息。產復因素如發病前發展遲緩和點頭癲病症呈高度相關”本研究所獲得之結果不僅可以幫助我們瞭解台灣點頭癲痛症之流行病學,也更清楚的詮釋了點頭癲痛症之相關病因。 A retrospective cohort with IS is obtained from one medical center to identify 69 IS cases (from 1985 to 1997), This cohort in conjunction with claim data from national health insurance was used to estimate prevalence, and incidence. A hospital-based case-control study was conducted to find out risk factors. Only 25 out of 69 IS are completed by telephone interview with questionnaire. A total of 106 subjects and 139 subjects in Disease Control and Normal Control, respectively were obtained as comparison groups. Unconditional logistic regression was used to calculate odds ratios and 95% CI. Incidence and prevalence (aged 0-9 years) are estimated as 0.06 per thousand live births and 0.05 per thousand. Significant prenatal factors include tuberous sclerosis, cerebral palsy, and other congenital anomalies. Neonatal asphyxia (perinatal factor) significantly accounts for the occurrence of IS. Developmental delay before onset of disease (postnatal factor) is highly associated with IS. Information obtained in this study not only make a clear understanding of disease burden of IS in this society but clarify more etiology of IS than before. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/26083 | 其他識別: | 892314B002145 | Rights: | 國立臺灣大學醫學院神經科 |
顯示於: | 醫學系 |
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892314B002145.pdf | 746.13 kB | Adobe PDF | 檢視/開啟 |
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