多巴胺代謝酵素MAOB及COMT基因多型性與早發型巴金森氏病易感性之相關研究
Date Issued
2001
Date
2001
Author(s)
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DOI
892314B002566
Abstract
The etiology of Parkinson's disease (PD) is uncertain. Genetic variation in the
enzymes involved in the inactivation of dopamine, such as monoamine oxidase B
(MAO-B) and catechol-O-methyltrasnferase (COMT) may influence the individual
susceptibility to PD. Recently, we found that PD patients having homozygous G
genotype have elevated risk of 2.2-fold that the control subjects in the development of
PD. Moreover, the frequency of homozygotes G genotype was higher in PD patients
who were younger than 61 years old, and a significantly synergistic enhancement was
noted in PD patients harboring genotypes of COMTL and variant G of MAOB
(OR=4.8). Accordingly, these effect might be pronounced in patients with youngonset
PD(YOPD), making them susceptible to earlier disease onset. Thus, in the
present study, we performed a case-control study, recruited 54 patients with YOPD (age
of onset is between 21-50) and 55 controls matched by sex and age, to investigate the
association of these two dopamine metabolizing gene polymorphisms with the PD
susceptibility and their potential interactions in young-onset PD patients.
Our study reveals a trend between genetic polymorphism of MAO-B in intron 13 and
susceptibility of YOPD. A allele may be a risk factor for YOPD (odds ratio=2.167) and it
influences more in men (odds ratio=5.571) then in women. These results are contrary to our
previous study in old-onset PD. In addition, genetic polymorphisms of COMT was not
associated with the susceptibility of YOPD. These results might suggest that young-onset PD
patients might share different etiology with the old-onset PD patients.
Subjects
Parkinson’s disease
young-onset
COMT
polymorphism
Publisher
臺北市：國立臺灣大學醫學院神經科
Type
journal article
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