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  4. 多巴胺代謝酵素MAOB及COMT基因多型性與早發型巴金森氏病易感性之相關研究
 
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多巴胺代謝酵素MAOB及COMT基因多型性與早發型巴金森氏病易感性之相關研究

Date Issued
2001
Date
2001
Author(s)
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DOI
892314B002566
URI
http://ntur.lib.ntu.edu.tw//handle/246246/26085
Abstract
The etiology of Parkinson's disease (PD) is uncertain. Genetic variation in the enzymes involved in the inactivation of dopamine, such as monoamine oxidase B (MAO-B) and catechol-O-methyltrasnferase (COMT) may influence the individual susceptibility to PD. Recently, we found that PD patients having homozygous G genotype have elevated risk of 2.2-fold that the control subjects in the development of PD. Moreover, the frequency of homozygotes G genotype was higher in PD patients who were younger than 61 years old, and a significantly synergistic enhancement was noted in PD patients harboring genotypes of COMTL and variant G of MAOB (OR=4.8). Accordingly, these effect might be pronounced in patients with youngonset PD(YOPD), making them susceptible to earlier disease onset. Thus, in the present study, we performed a case-control study, recruited 54 patients with YOPD (age of onset is between 21-50) and 55 controls matched by sex and age, to investigate the association of these two dopamine metabolizing gene polymorphisms with the PD susceptibility and their potential interactions in young-onset PD patients. Our study reveals a trend between genetic polymorphism of MAO-B in intron 13 and susceptibility of YOPD. A allele may be a risk factor for YOPD (odds ratio=2.167) and it influences more in men (odds ratio=5.571) then in women. These results are contrary to our previous study in old-onset PD. In addition, genetic polymorphisms of COMT was not associated with the susceptibility of YOPD. These results might suggest that young-onset PD patients might share different etiology with the old-onset PD patients.
Subjects
Parkinson’s disease
young-onset
COMT
polymorphism
Publisher
臺北市:國立臺灣大學醫學院神經科
Type
journal article
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