DC 欄位 | 值 | 語言 |
dc.contributor.author | ���F�� | zh-TW |
dc.creator | 陳達夫 | zh_TW |
dc.date | 2002 | - |
dc.date.accessioned | 2006-07-26T04:24:12Z | - |
dc.date.accessioned | 2018-07-12T01:37:38Z | - |
dc.date.available | 2006-07-26T04:24:12Z | - |
dc.date.available | 2018-07-12T01:37:38Z | - |
dc.date.issued | 2002 | - |
dc.identifier | 902314B002264 | zh_TW |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/26089 | - |
dc.description.abstract | 蛋白質FE65 可與Amyloid Precursor Protein 之細胞內段結合,並進而改變乙型類澱粉之代
謝;近來許多研究探討FE65 基因多型性變異與老年偶發性阿滋海默症的關係。這是台灣首次
進行相關的研究,我們收集了66 位老年偶發性阿滋海默症的病患,及78 位年齡、教育程度
相當之正常參與者,其中絕大多數是”11”基因型,只有一位正常者具有”12” 基因型;因此,
就台灣族群而言,FE65 基因多型性變異與老年偶發性阿滋海默症的發生並無顯著關係。 | zh_TW |
dc.description.abstract | The FE65 protein binds to the intracellular domain of the amyloid precursor protein (APP), and
may regulate the metabolism of Aβ. A genetic polymorphism in intro 13 of the FE65 gene has
been reported to be associated with the sporadic late-onset Alzheimer’s disease (AD) recently. This
is a similar investigation in Taiwan. We collect 66 AD patients, and 78 control subjects nearly
matched with age and education level. Most of them have the same “11” genotype, and only one
“12” genotype in the control group. In conclusion, there is no association between the FE65
polymorphism and sporadic late-onset Alzheimer’s disease. | en |
dc.format | application/pdf | zh_TW |
dc.format.extent | 44439 bytes | - |
dc.format.mimetype | application/pdf | en |
dc.language | zh-TW | zh_TW |
dc.language.iso | zh_TW | - |
dc.publisher | 臺北市:國立臺灣大學醫學院神經科 | zh_TW |
dc.rights | 國立臺灣大學醫學院神經科 | zh_TW |
dc.subject | FE65 | zh_TW |
dc.subject | 基因多型性變異 | zh_TW |
dc.subject | 阿滋海默症 | zh_TW |
dc.subject | polymorphism | en |
dc.subject | Alzheimer’s disease | en |
dc.title | 行政院國家科學委員會補助專題研究計畫成果報告:FE65基因多型性變異與老年性阿滋海默症相關性之本土研究 | zh_TW |
dc.type | journal article | en |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/26089/1/902314B002264.pdf | - |
dc.coverage | 計畫年度:90;起迄日期:2001-08-01/2002-07-31 | zh_TW |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | zh_TW | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
顯示於: | 醫學系
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