https://scholars.lib.ntu.edu.tw/handle/123456789/197985
標題: | Effects of Aging on Human Skin Innervation | 作者: | CHANG, YANG-CHYUAN LIN, WHEI-MIN HSIEH, SUNG-TSANG |
公開日期: | 2004 | 卷: | v.15 | 期: | n.1 | 起(迄)頁: | 149-153 | 來源出版物: | NEUROREPORT | 摘要: | To understand the effect of aging on human skin innervation, we investigated intraepidermal nerve fiber (IENF) density of skin biopsies. IENF densities of the distal leg were lower in elderly (>= 60 years of age ) than in young adults ( 19-39 years of age; 7.80 +/- 0.79 vs 13.55 +/- 0. 85 fibers/ mm, p < 0.01). A similar trend was also observed in the distal forearm (11.67 +/- 1.55 vs 19.39 +/- 1.60 fibers/mm, p < 0.001). IENF densities were negatively correlated with age according to multiple linear regression analysis on the entire study population (age range: 19-78 years) with standardized coefficients of -0.462 (p < 0.001) in the distal leg and -0.335 (p = 0.005) in the distal forearm. These findings suggest a significant reduction in IENF densities with age. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/91456 |
顯示於: | 醫學系 |
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