https://scholars.lib.ntu.edu.tw/handle/123456789/198040
Title: | Seizure Frequency Affects Event-Related Potentials (P300) in Epilepsy | Authors: | CHEN, RONG-CHI TSAI, SONG-YEN CHANG, YANG-CHYUAN LIOU, HORNG-HUEI |
Keywords: | TEMPORAL-LOBE EPILEPSY;EVOKED-POTENTIALS;REACTION-TIME;LATENCY;AGE;ATTENTION | Issue Date: | 2001 | Journal Volume: | v.8 | Journal Issue: | n.5 | Start page/Pages: | 442-446 | Source: | JOURNAL OF CLINICAL NEUROSCIENCE | Abstract: | To analyse the effect of epilepsy an P300 event-related potentials we studied 27 patients with idiopathic generalized epilepsy (IGE), 13 patients with temporal lobe epilepsy (TLE) and 60 normal controls. The prolongation of P 300 latencies was highly correlated with increasing age in controls but not epileptic patients. The age-corrected P300 latency used in this study was actual P300 latency-predicted P300 latency ( predicted P300 (msec) = 306.20 + 0.79 age, P< 0.001, R-2 =0.32). By using ANOVA analysis, the age- corrected latencies of P300 were significantly longer in TLE patients (19.72 +/- 47.82 msec, mean +/- SD) than in IGE patients (10.97 +/- 36.97 msec) and controls (0.23 +/- 20.28 msec). Likewise, significantly prolonged P300 latencies were seen in the epileptic patients with a seizure frequency more than 400 times (37.21 +/- 47.50 msec). The multivariate-adjusted odds ratio for those who had TLE was 10.97 (95% Cl = 3.99 - 30.14) in the prolonged latencies of P300 compared with that of IGE patients. The odds ratio of longer latencies of P300 was 7.43 (95% Cl = 2.75 - 20.08) among those who had a high seizure frequency ( |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/99659 |
Appears in Collections: | 醫學系 |
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