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  4. The Diagnostic Value of Sensory Evoked Potentials in Pediatric Wilson Disease
 
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The Diagnostic Value of Sensory Evoked Potentials in Pediatric Wilson Disease

Resource
PEDIATRIC NEUROLOGY v.29 n.1 pp.42-45
Journal
PEDIATRIC NEUROLOGY
Journal Volume
v.29
Journal Issue
n.1
Pages
42-45
Date Issued
2003
Date
2003
Author(s)
HSU, Y-S
CHANG, YANG-CHYUAN
LEE, WANG-TSO
NI, YEN-HSUAN
HSU, HONG-YUAN
CHANG, MEI-HWEI
URI
http://ntur.lib.ntu.edu.tw//handle/246246/99668
Abstract
We studied the sensory evoked potentials in pediatric Wilson disease to verify their subclinical neurologic involvement and to elucidate the role of cirrhosis in abnormal evoked potentials in non-neurologic Wilson disease. Thirty children (17 male, 13 female), diagnosed with Wilson disease before 18 years, were enrolled. The mean age during studies was 15 . 8 +/- 6.3 years, and disease duration since diagnosis was 3 . 0 +/- 3.3 years. In 12 neurologic Wilson disease cases, there were prolonged interpeak latencies of brainstem auditory evoked potentials III-V, IN, somatosensory evoked potentials N13-N20 (P < 0.01 vs controls and non- neurologic cases), and P100 latency (P < 0.01 vs controls). All 12 patients had at least one abnormal evoked potential, including 91.7% brainstem auditory, 58.3% somatosensory, and 25% visual evoked potentials. In 18 non-neurologic Wilson disease cases, there were still prolonged interpeak latencies for brainstem auditory evoked potentials IN and somatosensory evoked potentials N13-N20 (P < 0.05 vs controls), with 27.8% of them having at least one abnormal evoked potential, including 16.6% brainstem auditory, 5.6% somatosensory, and 11.1% visual evoked potentials . In those with non-neurologic Wilson disease, there were no significant differences in all the evoked potential parameters between the cirrhotic and non-cirrhotic patients. (C) 2003 by Elsevier Inc. All rights reserved.
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