|Title:||Snp Fine Mapping of Chromosome 8p21-12 Reveals Four Potential Candidate Genes for Schizophrenia, Dpysl2, Trim35, Ptk2b, and Chrna2||Authors:||LIU, CHIH-MIN
|Issue Date:||2005||Journal Issue:||n.1||Start page/Pages:||126-126||Source:||AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS v .138B||Abstract:||
Introduction: There was suggestive linkage evidence of chromosome 8p21-12 to schizophrenia in our previous linkage study. Methods: In this study, we conducted a two-stage approach for further fine mapping. In the first stage, 171 single nucleotide polymorphisms (SNPs) around D8S1222 with average intermarker distance of 27 kbp were selected from the public database for SNP validation in a subset of our sample. Of the 171 SNPs selected, 101 SNPs met the validation criterion of minor allele frequency above 10%. In the second stage, we genotyped the 101 validated SNPs in 216 families with at least 2 siblings affected with schizophrenia. Results: We found the SNP (rs4733044) of dihydropyrimidinase-like 2 (DPYSL2), the SNP (rs2322604) of tripartite motif-containing 35 (TRIM35), and the SNP ( rs 7007145) of cholinergic receptor, nicotinic, alpha polypeptide 2 ( neuronal) (CHRNA2) were significantly associated with schizophrenia (p < 0 .05) through single locus association analysis using either Transmit or FBAT program. The haplotype block of two SNPs in the genomic region of DPYSL2 and the haplotype block of six SNPs across the genomic regions of TRIM35 and protein tyrosine kinase 2 beta (PTK2B), and the haplotype block of 3 SNPs across the genomic regions of PTK2B and CHRNA2 were significantly associated with schizophrenia (p < 0.05) through haplotype association analysis. Conclusions: These results suggest that DPYSL3, TRIM 35, PTK2B and CHRNA2 may be potential candidate genes for schizophrenia in the 8p21-12 region. Replication in another sample is warranted.
|Appears in Collections:||醫學系|
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