https://scholars.lib.ntu.edu.tw/handle/123456789/198576
標題: | Snp Fine Mapping of Chromosome 22q12 Reveals the Novel Vulnerability Gene for Schizophrenia, Cacng2: Association with Impairment of Sustained Attention and Executive Function | 作者: | LIU, YU-LI FANN, CATHY SHENG-JIUAN LIU, CHIH-MIN 陳為堅 |
公開日期: | 2005 | 期: | n.1 | 起(迄)頁: | 126-126 | 來源出版物: | AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS v .138B | 摘要: | Introduction: The D22S278 marker of chromosome 22q12 had shown the highest linkage association with schizophrenia in our previous study. Methods: According to this result, we conducted further fine mapping by using the criterion of minor allele frequency above 10%. We selected 47 single nucleotide polymorphisms (SNPs) from 94 potential markers around 1 Mb of D22S278 in 95 individuals. We then genotyped these 47 validated SNPs by MALDI-TOF MS method in 218 pedigrees with at least 2 siblings affected with schizophrenia. Results: We found three genes MCM5 (rs875400) , RASD2 (rs736212), and CACNG2 (rs2283986 and rs2092662) significantly associated with schizophrenia in single locus association analyses (p < 0.05). There were five haplotypes in four genes APOL5 (rs1540297-rs2899256-rs2076671- rs879680) , MYH-9 (rs2481-rs875726-rs1009150) and (rs3752463-rs1557540 -rs 713839-rs739097), EIF3S7 (rs140002-rs2142824), and CACNG2 (rs2267360-rs 140526-rs1883987-rs916269), showed significantly associations with schizophrenia (p < 0.05). When correlate these five haplotypes with sustained attention deficits assessed by Continuous Performance Test and executive functions assessed by Wisconsin Card Sort Test , the single locus and the haplotype G-T-A-G of CACNG2 gene showed significant associations with both neuropsychological assessments (p < 0.05). Conclusions: These results suggest that the CACNG2 gene may be a novel susceptibility gene of schizophrenia in the 22q12 region. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/89577 |
顯示於: | 醫學系 |
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