https://scholars.lib.ntu.edu.tw/handle/123456789/198647
標題: | Comparison of Haloperidol and Reduced Haloperidol Plasma-Levels in 4 Different Ethnic Populations | 作者: | CHANG, WEN-HO LIN, SHIH-KU CHEN, TENG-YI CHEN, HORNG LIN, HSIN-NAN HWU, HAI-GWO CHIEN, CHING-PIAO |
關鍵字: | ETHNICITY;HALOPERIDOL;REDUCED HALOPERIDOL;SCHIZOPHRENIC- PATIENTS;PSYCHIATRIC-PATIENTS;CLINICAL-RESPONSE | 公開日期: | 1992 | 卷: | v.16 | 期: | n.2 | 起(迄)頁: | 193-202 | 來源出版物: | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY AND BIOLOGICAL PSYCHIATRY | 摘要: | 1. Plasma haloperidol and reduced haloperidol concentration were measured in four ethnic populations. 2. Plasma samples were obtained under steady- state conditions and obtained 10- 12 hours post bedtime dose and prior to the morning dose. 3. Haloperidol and reduced haloperidol plasma levels were assayed by radioimmunoassay and liquid chromatography. 4. A wide interpatient variability between haloperidol dose and plasma concentration was observed for each ethnic group. 5. The Chinese group differed from the other ethnic populations . 6. A nonlinear relationship was observed between haloperidol and reduced haloperidol plasma levels in each ethnic group. Further, the relationship of haloperidol to reduced haloperidol plasma levels differed for each ethnic group. These results suggest that various ethnic groups could metabolize haloperidol and reduced haloperidol differently. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/94655 |
顯示於: | 醫學系 |
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