|Title:||Concordance of Positive and Negative Symptoms in Coaffected Sib-Pairs with Schizophrenia||Authors:||HWU, HAI-GWO
|Issue Date:||1997||Journal Volume:||v.74||Journal Issue:||n.1||Start page/Pages:||1-6||Source:||AMERICAN JOURNAL OF MEDICAL GENETICS||Abstract:||
Positive and negative symptom (NGS) dimensions were examined for their concordance in 46 coaffected schizophrenic sib-pairs. Results showed that the symptom dimensions of negative symptoms (NGS), delusion- hallucination (DHS), and thought disorganization (TDS) could be formulated . Discrete genetic endowment of these three symptom dimensions was not found as shown by the low concordance in sib pair analysis (kappa = 0.20-0 .30). Thirty -seven pairs (80.4%) and 21 pairs (45.7%) had liability, defined by the presence of NGS in any one member of the coaffected sib- pairs, of NGS of "any degree", and of"severe degree" in 46 sib-pairs, respectively. Both groups had high prevalence (59.1-81.0%) of positive symptoms. Another 9 (19. 6%) and 25 (54.3%) pairs had no liability of NGS of "any degree" or of "severe degree" out of 46 sib- pairs, respectively. These two groups had high concordance ( Kappa = 0.45-1.00) of TDS or DHS between coaffected sib- pairs. Based on the results, it is hypothesized that schizophrenia, as defined by DSM-III-R, may consist of two subtypes: one has liability of NGS and a high prevalence of positive symptoms, while the other has only positive symptoms.
|Appears in Collections:||醫學系|
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