https://scholars.lib.ntu.edu.tw/handle/123456789/198677
標題: | No Association of Dopamine D2 Receptor Molecular Variant Cys311 and Schizophrenia in Chinese Patients | 作者: | CHEN, CHIA-HSIANG CHIEN, SHIH-HSIANG HWU, HAI-GWO |
公開日期: | 1996 | 卷: | 67 | 期: | 4 | 起(迄)頁: | 418-420 | 來源出版物: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics | 摘要: | A serine-to-cysteine mutation of dopamine D2 receptor at codon 311 ( Cys311) was found to have higher frequency in schizophrenic patients than in normal controls in Japanese by Arinami et al [1994: Lancent 343: 703- 704]. The Cys311 allele was found to be associated with patients with younger age-of-onset, positive family history and more positive symptoms. To investigate the possible involvement of Cys311 in schizophrenia in Chinese population, 114 unrelated Taiwanese Chinese schizophrenic patients with positive family history and 88 normal controls were genotyped for Cys 311. Four patients and 5 normal controls were heterozygotes of Ser311/ Cys311, no homozygotes of Cys311 was identified in either group. The allele frequencies of Cys311 in Chinese schizophrenic patients and normal controls were 2% and 3 %, respectively. No significant difference was detected between two groups. Our results do not support the argument that the Cys311 allele of DRD2 is a genetic risk for certain types of schizophrenia in Chinese populations. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/105074 |
顯示於: | 醫學系 |
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