|Title:||Linkage of Schizophrenia with Chromosome 1q Loci in Taiwanese Families||Authors:||Hwu, H-G
Fann, C S-J
Lee, S F-C
|Keywords:||POTASSIUM CHANNEL GENE;MULTIPLE SUSCEPTIBILITY LOCI;GENOME- WIDE SEARCH;DUFFY BLOOD-GROUP;BIPOLAR DISORDER;CAG REPEAT||Issue Date:||2003||Source:||MOLECULAR PSYCHIATRY||Journal Volume:||v.8||Journal Issue:||n.4||Start page/Pages:||445-452||Abstract:||
A positive linkage of schizophrenia with chromosome 1q loci has been reported in Caucasian patients. This study was designed to evaluate the linkage of schizophrenia with markers of the 1q22-44 region in 52 Taiwanese families with at least two affected siblings. In the region 1q 2231 (17.8cM ), marker D1S1679 had a maximal proportion (0.57, P=0.03) of shared identity by descent (IBD) under a narrow phenotype ( DSM-IV schizophrenia only). In the region 1q42-44 (26.8cM), the marker D1S251, located near the breakpoint of a balanced translocation t (1;11) (q42.1;q 14.3) segregated with schizophrenia, and also near the neurodevelopment- related'Disrupted in Schizophrenia 1' gene, had a maximum NPL score of 1. 73 (P=0.03) under the narrow phenotype model and 2.18(P = 0.01) under the broad phenotype model comprised of schizophrenia, schizoaffective disorder , and other nonaffective psychotic disorders as defined by DSM-IV criteria . The marker D1S2836 also had a maximal proportion ( 0.57, P = 0.05) of shared IBD under the broad model. These findings may provide guidance for positional cloning studies on candidate genes in the 1q22-31 and 1q41-44 regions.
|Appears in Collections:||醫學系|
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