https://scholars.lib.ntu.edu.tw/handle/123456789/198690
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 精神科 | en |
dc.contributor.author | Hwu, H-G | en |
dc.contributor.author | Liu, C-M | en |
dc.contributor.author | Fann, C S-J | en |
dc.contributor.author | Ou-Yang, W-C | en |
dc.contributor.author | Lee, S F-C | en |
dc.contributor.author | 胡海國 | zh_TW |
dc.contributor.author | 劉智民 | zh_TW |
dc.creator | 胡海國;劉智民 | zh_TW |
dc.creator | Hwu, H-G; Liu, C-M; Fann, C S-J; Ou-Yang, W-C; Lee, S F-C | en |
dc.date | 2003 | en |
dc.date.accessioned | 2009-01-20T10:25:22Z | - |
dc.date.accessioned | 2018-07-12T03:04:51Z | - |
dc.date.available | 2009-01-20T10:25:22Z | - |
dc.date.available | 2018-07-12T03:04:51Z | - |
dc.date.issued | 2003 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/105094 | - |
dc.description.abstract | A positive linkage of schizophrenia with chromosome 1q loci has been reported in Caucasian patients. This study was designed to evaluate the linkage of schizophrenia with markers of the 1q22-44 region in 52 Taiwanese families with at least two affected siblings. In the region 1q 2231 (17.8cM ), marker D1S1679 had a maximal proportion (0.57, P=0.03) of shared identity by descent (IBD) under a narrow phenotype ( DSM-IV schizophrenia only). In the region 1q42-44 (26.8cM), the marker D1S251, located near the breakpoint of a balanced translocation t (1;11) (q42.1;q 14.3) segregated with schizophrenia, and also near the neurodevelopment- related'Disrupted in Schizophrenia 1' gene, had a maximum NPL score of 1. 73 (P=0.03) under the narrow phenotype model and 2.18(P = 0.01) under the broad phenotype model comprised of schizophrenia, schizoaffective disorder , and other nonaffective psychotic disorders as defined by DSM-IV criteria . The marker D1S2836 also had a maximal proportion ( 0.57, P = 0.05) of shared IBD under the broad model. These findings may provide guidance for positional cloning studies on candidate genes in the 1q22-31 and 1q41-44 regions. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | MOLECULAR PSYCHIATRY v.8 n.4 pp.445-452 | en |
dc.relation.ispartof | MOLECULAR PSYCHIATRY | - |
dc.subject | POTASSIUM CHANNEL GENE | en |
dc.subject | MULTIPLE SUSCEPTIBILITY LOCI | en |
dc.subject | GENOME- WIDE SEARCH | en |
dc.subject | DUFFY BLOOD-GROUP | en |
dc.subject | BIPOLAR DISORDER | en |
dc.subject | CAG REPEAT | en |
dc.title | Linkage of Schizophrenia with Chromosome 1q Loci in Taiwanese Families | en |
dc.relation.pages | 445-452 | - |
dc.relation.journalvolume | v.8 | - |
dc.relation.journalissue | n.4 | - |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
顯示於: | 醫學系 |
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