https://scholars.lib.ntu.edu.tw/handle/123456789/199415
標題: | Comparison of cryoglobulinemia in children and adults | 作者: | Liou, Yu-Ting Huang, Jing-Long Ou, Liang-Shiou Lin, Yu-Hsuan Yu, Kuang-Hui Luo, Shue-Fen Ho, Huei-Huang Liou, Lieh-Bang Yeh, Kuo-Wei |
關鍵字: | Cryoglobulinemia;Hepatitis B virus;Hepatitis C virus | 公開日期: | 2013 | 起(迄)頁: | 59-64 | 來源出版物: | Journal of Microbiology Immunology and Infection | 摘要: | Background/Purpose: Cryoglobulinemic vasculitis is a systemic vasculitis resulting from circulating immune complex deposition in the small vessels and is characterized by variable clinical features, including purpura, Raynaud's syndrome, ulcerations, arthralgia, glomerulonephritis, and peripheral neuropathy. Cryoglobulinemia can also result from hepatitis C virus (HCV) infection. The clinical spectrum and associated or underlying diseases of cryoglobulinemia in different age groups is not well understood. This study investigated the demographic, clinical, serologic features, and associated or underlying diseases in children and adult patients with cryoglobulinemia. Methods: The retrospective study included 114 patients (18 children, 96 adults) who presented with cryoglobulinemia between 2000 and 2010 at the Chang Gung Memorial Hospital. Their medical records were reviewed and serological and virologic assessments were analyzed. Results: In this group of patients, children had a significantly higher prevalence of prolonged fever (16.7% vs. 3.13%; p = 0.018), arthralgia (66.67% vs. 16.67%; p < 0.001), arthritis (66.67% vs. 15.63%; p < 0.001) and cutaneous involvement (77.78% vs. 50%; p = 0.03) compared with adults. Both the adult and children groups had a greater frequency of hepatitis B virus (HBV) infection (20.8% and 5.6%, respectively), than HCV infection (12.5% and 0%, respectively). Conclusions: Children with cryoglobulinemia had a significantly higher prevalence of prolonged fever, arthralgia, arthritis and cutaneous involvement compared with adults. Copyright (c) 2011, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/260345 | DOI: | 10.1016/j.jmii.2011.12.027 | SDG/關鍵字: | adult; age distribution; arthralgia; arthritis; article; child; cryoglobulinemia; female; fever; hepatitis B; Hepatitis B virus; hepatitis C; Hepatitis C virus; human; major clinical study; male; preschool child; prevalence; school child; serodiagnosis; skin disease; Taiwan; Adult; Age Factors; Aged; Child; Child, Preschool; Cryoglobulinemia; Humans; Middle Aged; Prevalence; Retrospective Studies; Risk Factors; Taiwan |
顯示於: | 醫學系 |
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