|Title:||行政院國家科學委員會專題研究計畫期中進度報告:Muc5 AC-Diphtheria Toxin基因轉殖鼠之黏膜黏液素表現(1/3)||Authors:||王一中||Issue Date:||2005||Publisher:||臺北市：國立臺灣大學醫學院眼科||Abstract:||
The tear film is composed of an outer lipid layer and an inner aqueous phase,
which contains a variety of mucin, adjacent to the glycocalyx of the apical cells of the
epithelium. Mucins are a heterogenous group of O-linked glycoproteins, synthesized
and secreted primarily by goblet cells, which coat and protect mucosal epithelia.
Ocular surface mucin adheres to the glycocalyces of conjunctival and corneal
epithelial cells and enhances wetability of the cornea by serving as an interface
between the hydrophobic corneal epithelium and the aqueous tear fluid.1,2 Therefore,
mucin can stabilize the tear film, provide a smooth and refractive surface of high
optical quality over the cornea, lubricate the corneal and conjunctival epithelial
surfaces during eye blinking, and prevent desiccation of the ocular surface through
water retention. It also serves as a barrier to microbial invasion and shields
conjunctival and corneal cells from surface debris and noxious substances.3,4 As a
consequence of their extensive glycosylation, mucins offer a wide range of terminal
carbohydrate-related epitopes that can act as receptors for ligands expressed in certain
microorganisms and viruses. Consequently, ocular mucins may also prevent pathogen
penetrance by inhibiting bacterial adhesion to the ocular surface epithelium.
|Appears in Collections:||醫學系|
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