https://scholars.lib.ntu.edu.tw/handle/123456789/199813
標題: | 行政院國家科學委員會專題研究計畫成果報告:苗勒氏肌在甲狀腺上眼瞼攣縮致病機轉的角色 | 作者: | 廖述朗 | 公開日期: | 2005 | 出版社: | 臺北市:國立臺灣大學醫學院眼科 | 摘要: | Purpose: Among the clinical manifestations, upper lid retraction is the most common ocular sign of Graves’ ophthalmology (GO). Although several mechanisms have been postulated, the exact pathology of Müller’s muscle in pathogenesis of upper lid retraction is not fully elucidated. To study the relation between tissue pathology and the severity of upper lid retraction, we have created an innovative methodology to quantify the pathological changes. Methods & Materials: Twenty GO Müller’s muscles were consecutively collected, and the severity of upper lid retraction measured by MRD1 was also recorded. The excised Müller’s muscle was fixed in formalin and sectioned in 3-µ m thickness, which was stained serially with H&E, Toluidine blue, Masson’s trichrome stain, and several immunohistochemistries including LCA, CD3, CD20, CD68, HLA-DR, caspase 3, and TSHr. Results & Conclusion: We showed that the degree of fibrosis in the diseased Mü ller's muscle correlated with the severity of upper lid retraction especially in patients with severe GO. In addition, normal muscle volume was decreased and replaced by fat and fibrosis infiltration. However, there was no evidence of apoptosis in Müller's muscle. On the other hand, the number of macrophages increased in most of diseased Mü ller's muscles with predominant fibrotic changes, providing a role for macrophage during fibrogenesis. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/26748 | 其他識別: | 932314B002092 | Rights: | 國立臺灣大學醫學院眼科 |
顯示於: | 醫學系 |
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