高血脂症是否會誘發心肌肥厚及其致病機轉(2/3)

Abstract

本研究計畫執行的前兩年中，我們已建立起新生小鼠心臟細胞及人類臍帶血管內皮細胞培養的實驗模型，並將其應用於探討心血管疾病成因機制的研究。高脂血症是許多心臟血管疾病的重要因子，同時我們也注意到許多糖尿病患者常伴隨肥胖及高脂血症並併發心臟血管疾病，因此血糖濃度的變化亦是左右心臟血管疾病的重要因子之一。在我們的研究之中，我們將從細胞生物學的角度探討氧化態低密度脂蛋白（Oxidized LDL）及葡萄糖對血管內皮細胞及心臟肌肉細胞的影響。

In the first two years of this project, we have established culture systems of neonatal rat cardiomyocytes and human umbilical vain endothelial cells. We have applied these culture systems into our research of cardiac and vascular diseases. Dyslipidemia is an important risk factor for the cardiovascular disease. Many of the diabetic patients have dyslipidemia and suffer from cardiovascular syndromes. Therefore, the change of blood glucose is also an important factor for cardiovascular diseases. In our study, we have investigated the effects of oxidized LDL and glucose on our cell culture system.