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  4. Application of irradiation in limb allo-transplantation , a rat model
 
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Application of irradiation in limb allo-transplantation , a rat model

Date Issued
1998-07-31
Date
1998-07-31
Author(s)
雷德
DOI
872314B002002
URI
http://ntur.lib.ntu.edu.tw//handle/246246/25418
Abstract
Following whole limb transplantation from Brown-Norway (BN) to Lewis (LEW) rats, Graft-vs-Host Disease (GVHD) is observed after the administration of immunosuppressive agents is discontinued. In this study, lethal donor irradiation and variation in immunosuppressive schedules were studied in an attempt to prevent GVHD. In group one (n=4, control), all BN limbs were rejected by untreated LEW recipients in 7.5±0.3 days after transplantation. Combination cyclosporine (5 mg/kg/day) and leflunomide (10 mg/kg/day) were given orally to 3 additional groups of LEW recipients until 60 days following transplantation. In group 2 (n=6), drug treatment began 2 days prior to surgery. Over days 63 to 65, all recipients developed signs of GVHD. The limbs survived for 75.6±3.3 days. In group 3 (n=11), drug treatment began on the day of surgery. All but one rat developed signs of GVHD , comparable to that seen in group 2 , over days 63 to 65. The mean limb survival time was 83.6±5.7 days. In group 4 (n=6) donor rats were treated with total body irradiation (15 Gy) 2 days before surgery. Drug treatment of the LEW recipients began 2 days prior to surgery. Three of the 6 rats developed GVHD following discontinuation of drug treatment, and the mean limb survival time was 73.2±0.9 days. The incidence of GVHD was not significantly different (p=0.09, Fisher’s exact test) among the 3 treated groups. These results show that neither lethal donor total body irradiation or temporal variation in the administration of immunosuppressive agents can abolish GVHD in this model of whole limb allotransplantation.
Subjects
limb transplantation
GVHD
total body irradiation
Publisher
臺北市:國立臺灣大學醫學院放射線科
Type
journal article
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