https://scholars.lib.ntu.edu.tw/handle/123456789/201298
標題: | 動態對比劑顯影與顯微磁振造影影像在乳癌顯微循環及血管新生性之研究(2/2) Dynamic Contrast-enhanced and Microscopic MR imaging for Microcirculation and Angiogenesis of Breast Cancer (2/2) |
作者: | �i���� | 關鍵字: | magnetic resonance image;breast;chemotherapy;磁振造影;乳房;化學治療 | 公開日期: | 31-十月-2003 | 出版社: | 臺北市:國立臺灣大學醫學院放射線科 | 摘要: | During the second-year project, magnetic resonance (MR) angiogenetic parameters derived from dynamic contrast enhanced (DCE) MRI was applied to the whole tumor. We evaluated angiogenic compositions and tumor response in the course of neoadjuvant chemotherapy in patients with locally advanced breast cancer (LABC) using DCE MRI. Thirteen patients with LABC underwent serial DCE MRI (61 MR studies) during the course of chemotherapy. DCE MRI was quantified using a two-compartment model at pixel-by-pixel basis. Analysis of parametric histograms of amplitude, exchange rate kout and peak enhancement over the whole tumor was performed. The distribution patterns of histograms were correlated with the tumor response. Initial kurtosis and standard deviation of amplitude before chemotherapy correlated with tumor response. Comparing the initial values with the values after the first course of chemotherapy, tumor response was associated with decrease in standard deviation of amplitude, and increase in kurtosis and decrease in standard deviation of kout. Comparing the initial values with the values after completing the chemotherapy, tumors with better response were associated with increase in kurtosis (r2=0.39), decrease in mean (r2=0.71) and standard deviation (r2=0.59) of amplitude, and decrease in mean of peak enhancement (r2=0.50). Our results suggested that tumors with better response tended to alter their internal compositions from heterogeneous to homogeneous distributions and to decrease in peak enhancement after chemotherapy. Serial analyses of parametric histograms of DCE MRI-derived angiogenic parameters can monitor the response of angiogenic compositions of a tumor throughout the course of chemotherapy, and is capable of predicting tumor response early in the course. 本研究第二年計劃,使用由磁振造影動態顯影衍生之血管新生性參數於整個乳房腫瘤之分 析。我們評估局部侵襲性乳癌在化學治療當中以動態顯影磁振造影所獲相關血管新生性組成及 腫瘤反應。在本研究中總共包含13 個病患,接受了61 次磁振造影檢查。所獲得之資料使用二 隔間模式以像素為基礎加以分析。而整個腫瘤參數組織圖之分析包括輻度(amplitude)、交換速 率(exchange rate, Kout)及最高顯影。腫瘤治療之反應與參數組織圖之分佈情況加以比較。我們 發現初次檢查獲得輻度之Kurtosis 及標準差與腫瘤反應相關,比較接受完第一次化學治療與初 次化學治療前之參數值,我們發現腫瘤反應與輻度標準差下降,交換速率Kout 的Kurtosis 增加 與Kout 標準差之下降有關,而完成化學治療與初次化學治療前之比較,結果顯示輻度分佈之 Kurtosis 增加(r2 = 0.39)、平均值下降(r2 = 0.71)、標準差下降(r2 = 0.59)及最高顯影之平均 值下降(r2 = 0.50)與腫瘤反應有關。 我們的研究結果顯示有較佳腫瘤治療反應者通常在治療中其內在組成會由較不均勻變為較 均勻之分佈,而最高顯影之強度亦會在治療後下降,系列參數組織圖之分析可以監測在整個化 學治療過程中血管新生性組成之變化,而且可以於治療早期預測腫瘤反應。 |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/25432 | 其他識別: | 912314B002234 | Rights: | 國立臺灣大學醫學院放射線科 |
顯示於: | 醫學系 |
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