Diffusion tensor imaging of children with malignant phenylketonuria
Date Issued
2004-07-31
Date
2004-07-31
Author(s)
�^�H�{
DOI
922320B002107
Abstract
Purpose: Diffusion tensor images (DTIs) are used to demonstrate the supratenorial white
matter changes of malignant phenylketonuria (PKU) patients.
Materials and Methods: The intelligence and diffusion tensor imaging parameters (including first,
second and third eigen values (EVs), apparent diffusion coefficients (ADCs), and fractional
anisotropy (FA) in the fronto-parietal, parieto-occipital, frontal and central white matter, and the
anterior as well as posterior corpus callosum were assessed in 12 early-treated, chronic, stable
malignant PKU patients.
Results: Our findings indicated that EV2, EV3 and FA of the parieto-occipital white matter areas
were significantly different in study and control groups of patients older than three years of age.
In addition, EV3 and ADC of the parieto-occipital white matter were significantly negatively
correlated with verbal intelligence quotient (VIQ; r = -0.79, p = 0.04), and performance
intelligence quotient (r = -0.93, p = 0.03), respectively. FA of the parietal central white matter
was positively correlated with VIQ (r = 0.75, p = 0.05).
Conclusion: Though treated early, these chronic, stable malignant PKU patients still had
abnormal DT tensor imaging findings in the parieto-occipital central white matter. EV2, EV3 and
FA maps are potential tools for demonstrating brain changes stemming from malignant PKU.
Subjects
diffusion tensor
brain
magnetic resonance (MR)
pediatric
phenylketonuria
Publisher
臺北市：國立臺灣大學醫學院放射線科
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
922320B002107.pdf
Size
50.32 KB
Format
Adobe PDF
Checksum
(MD5):ada6acb9297ab6409c2e3652f2948208