|Title:||Computed tomography of the brain in patients with serum prolactin levels over 200 ng/ml||Authors:||CHANG, YEUN-CHUNG
HSU, JANE CHIEN-YAO
|Keywords:||CT, PITUITARY GLAND, HYPERPROLACTINEMIA||Issue Date:||1991||Source:||JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION||Journal Volume:||v.90||Journal Issue:||n.2||Start page/Pages:||146-52||Abstract:||
We reviewed the computed tomographic (CT) findings of the sella turcica in 26 patients with a serum prolactin level of over 200 ng/ml. The interval between the dates of CT examination and checking of the serum prolactin level were within 2 months. There were 24 nonpregnant women with a mean age of 30 years and 2 men with a mean age of 28.5 years . None of them were taking medication known to cause an elevation in serum prolactin levels. Surgery was performed on 8 patients with chromophobe adenomas of the pituitary gland: 6 of them were proven to have prolactin- secreting tumors (prolactinomas) after performing a special stain, and the remaining 2 patients, clinically diagnosed as prolactinomas, showed extremely high serum prolactin levels (3,200 and 2,251 ng/ml, respectively ). CT studies showed that the height of the pituitary gland in the coronal sections were more than 7 mm in 15 cases (58%) and more than 10 mm in 13 cases (50%); focal bulging of the diaphragma sellae in 16 cases (62 %); erosion of the sellar floor in 20 case (77%); deviation of the pituitary stalk in 19 cases (73 %); and abnormal attenuation or enhancement of the pituitary gland in 18 cases (69%). Three patients (12% ) showed no evidence of any abnormal CT finding despite a hyper- prolactinemic state of over 200 ng/ml. Six histologically proven cases ( 23%) of prolactinomas and chromophomas showed radiologic evidence of caverenous sinus invasion. We conclude that patients with a serum prolactin level higher than 200 ng/ml generally show significant changes in the sella turcica in CT.
|Appears in Collections:||醫學系|
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