https://scholars.lib.ntu.edu.tw/handle/123456789/201407
標題: | Unexpected Rapid Progression of Metastatic Adenoid Cystic Carcinoma during Treatment with Imatinib Mesylate | 作者: | YEN, RUOH-FANG JENG, YUNG-MING TZEN, KAI-YUAN HSU, CHIUN HONG, RUEY-LONG |
關鍵字: | adenoid cystic carcinoma;imatinib mesylate;KIT;PDGFR | 公開日期: | 2005 | 卷: | v.27 | 期: | 1027 | 起(迄)頁: | - | 來源出版物: | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 摘要: | Background. There is a lack of effective treatment for metastatic adenoid cystic carcinoma (ACC), a usually indolent tumor. We studied the efficacy of imatinib mesylate , a potent inhibitor of KIT tyrosine kinase, in patients with KIT-positive metastatic ACC. Methods. Five patients with lung metastasis were treated in a pilot study with imatinib 400 mg by mouth twice a day. Mutations of c-kit and platelet-derived growth factor receptor (PDGFR)-alpha in tumors from these patients were analyzed. Results. Disease progression was noted in three of five patients during the short treatment periods, ranging from 2 to 3 weeks. Three patients died of disease within 6 months. No detectable mutations were found in c- kit and PDGFR-alpha. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/93712 |
顯示於: | 醫學系 |
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