https://scholars.lib.ntu.edu.tw/handle/123456789/201447
標題: | Comparing Whole Body 18f-2-Deoxyglucose Positron Emission Tomography and Technetium-99m Methylene Diophosphate Bone Scan to Detect Bone Metastases in Patients with Non-Small Cell Lung Cancer | 作者: | YEN, RUOH-FANG | 關鍵字: | 18F-2-deoxyglucose;positron emission tomography;technetium- 99m methylene diophosphate;bone scan;bone metastases;non- small cell lung cancer | 公開日期: | 2002 | 卷: | v.49 | 期: | n.4 | 起(迄)頁: | 267-271 | 來源出版物: | NEOPLASMA | 摘要: | Despite advances in morphological imaging, some patients with non-small cell lung cancer (NSCLC) are found to have non-resectable disease at surgery or die of recurrence within a year of surgery. At present, metastatic bone involvement is usually assessed using conventional technetium-99m methylene diophosphate (Tc-99m MDP) whole body bone scan ( bone scan), which has a high sensitivity but a poor specificity. We have attempted to evaluate the usefulness of whole body positron emission tomography with 18F-2-deoxyglucose (FDG-PET) for the detection of malignant bone metastases of NSCLC, and to compare FDG-PET results with Bone Scan findings. Forty-eight patients with biopsy- proven NSCLC and suspected to have stage IV disease underwent whole body bone scan and FDG- PET to detect bone metastases. The final diagnoses of bone metastases were established by operative, histopathological findings or clinical follow- up longer than 1 year by additional radiographs or following FDG-PET/Tc-99 m MDP bone scan findings showing progressively and extensively widespread bone lesions. A total of 138 bone lesions found on either FDG-PET or Tc-99 m MDP bone scan were evaluated. Among the 106 metastatic and 32 benign bone lesions, FDG-PET and Tc-99 m MDP bone scan could accurately diagnose 99 and 98, as well as 30 and 2 metastatic and benign bone lesions, respectively. Diagnostic sensitivity and accuracy of FDG-PET and Tc-99m MDP bone scan were 93.4% and 92.5%, as well as 93.5% and 72.5%, respectively. In conclusion, our data suggest that FDG-PET with the same sensitivity and a better accuracy than those of Tc-99m MDP bone scan to detect metastatic bone lesions in patients with biopsy-proven NSCLC and suspected to have stage IV disease. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/96957 |
顯示於: | 醫學系 |
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