Emergence of Infections Caused by Vancomycin-resistant Susceptibility, and Molecular Epidemiology
Date Issued
1999-07-31
Date
1999-07-31
Author(s)
陸坤泰
DOI
882314B002059
Abstract
To understand the epidemiology of
vancomycin-resistant enterococci (VRE) in a
university hospital in Taipei, Taiwan. A
retrospective review over a 27-month period,
from March 1996 to May 1998 was
performed. Patients with VRE isolated from
any body site were identified through hospital
microbiology and infection control records.
Patient charts were reviewed for clinical and
epidemiology data, including age, gender,
previous hospital admissions, underlying
diseases, types of infection, and recent
antibiotic use. Twenty-five isolates of
VRE recovered from 12 patients were
identified. One patient with a perianal
abscess had 12 isolates of VRE (four isolates
of Enterococcus faecalis, seven of E faecium,
and one of E casseliflavus) recovered from
perianal lesions. Among three patients who
were hospitalized in the same room, one had
a community-acquired cellulitis over the left
leg caused by E faecalis and the other two
patients both had anal colonization with two
isolates of E faecalis. The other eight patients
had one E faecalis isolate each from various
clinical specimens. All isolates possessed
vanA resistance phenotype and vanA genes.
Multiple species of VRE (E faecalis, E
faecium. and E casseliflavus) and multiple
clones of E faecium could colonize in and/or
infect hospitalized patients. In addition,
same clones of VRE can persist long-term in
patients’ lower gastrointestinal tract.
Different antibiotypes and RAPD patterns of
the isolates from different patients excluded
the possibility of nosocomial spread at the
hospital. These results extend our knowledge
of the coexistence and the persistence of
multiple species and multiple clones of VRE
in hospitalized patients.
Subjects
Vancomycin-resistant enterococci
clonal dissemination
Publisher
臺北市：國立臺灣大學醫學院檢驗醫學科
Type
journal article
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