Epidemiologic Study on Ceftazidime-resistant Pseudomonas aeruginosa Infections in an Infensive Care Burn Unit
Date Issued
1999-07-31
Date
1999-07-31
Author(s)
���դ�
DOI
882314B002065
Abstract
Long-term colonization of various body
sites with subsequent severe infections in
burn patients by a multidrug-resistant
Pseudomonas aeruginosa clone (resistant to
piperacillin, cefoperazone, ceftazidime,
aztreonam, imipenem, cefepime, cefpirome,
ofloxacin, ciprofloxacin, minocycline, and
aminoglycosides) has not been previously
reported. Thirty-nine isolates of multidrugresistant
P. aeruginosa (resistant to
ceftazidime and at least three of the agents
listed above) recovered from various clinical
samples of three patients in an intensive care
burn unit, and seven preserved isolates
recovered from six patients in other medical
wards at National Taiwan University
Hospital were studied for their
epidemiological relatedness. The epidemic
could be attributed to a multidrug-resistant P.
aeruginosa clone belonging to serogroup O:F
(serogroup O:4) by means of antimicrobial
susceptibility, O-serogrouping, and random
amplified polymorphic DNA (RAPD)
patterns generated by arbitrarily primed PCR
(APPCR) of the isolates. The epidemic
strain persisted in the three patients for weeks
to months; in the meanwhile these patients
had received multiple antimicrobial agents
for management of intervenient episodes of
invasive infections (bacteremia, ventilatorassociated
pneumonia, and/or catheter-related
sepsis) caused by this strain, as well as
concomitant infections due to other
organisms. The strain had been isolated
only once previously from a burn patient of
the unit in December 1996. The present
study describing a small outbreak due to P.
aeruginosa documents that a single clone of
multidrug-resistant P. aeruginosa can cause
long-term persistence in different body sites
of burn patients and subsequently result in
various severe infections.
Subjects
Pseudomonas aeruginosa
burn unit
clonal dissemination
Publisher
臺北市：國立臺灣大學醫學院檢驗醫學科
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
882314B002065.pdf
Size
42.11 KB
Format
Adobe PDF
Checksum
(MD5):e0129d7ea92f572c9e01bf32324d76de