Expression of Adhesion Molecules in Cells of Malignant Pleural Effusions
Date Issued
1999-07-31
Date
1999-07-31
Author(s)
郭壽雄
DOI
882314B002205
Abstract
Background: The expression of adhesion
molecules on the surface of tumor cells has
been found to be related to the invasiveness
and metastasis of the neoplasm. The role of
adhesion molecules on the cells of malignant
pleural effusion has not been reported in the
literature.
Purposes: To observe the expression of
adhesion molecules on the cells in malignant
pleural effusion.
Design: Fifteen histologically/cytologically
verified malignant pleural effusions were
enrolled in this study. The cells prepared
with cytospin were stained with a pannel of
adhesion molecules by ABC peroxidase
method. The percentage of cells with
expression of adhesion molecules were
counted with a microscope.
Results: The most common adhesion
molecules on the cancer cells are CD44 (64%)
and E-cadherin (60%); on mesothelial cells
are CD44 (72%) and VLA-4 (57%). Those
on leukocytes are CD44 (72%) and LFA-1
(71%).
Discussion: Previous in vitro study
revealed the cancer cells with expression of
CD44 and E-cadherin were more invasive &
metastatic. This study showed that the
cancer cells in pleural effusion had high
percentage of cells with CD44 and Ecadherin.
This study confirmed the
previous observation in different malignant
cells in vivo.
Comment: This is the first in vivo study
that confirmed the malignant cells in pleural
effusions expressied adhesion molecules of
CD44 and E-cadherin. Due to technical
difficulty, the role of adhesion molecule in
the cell-to-cell interaction could not be
clearly demonstrated.
Subjects
malignant pleural effusion
adhesion molecule
Ecadherin
SDGs
Publisher
臺北市：國立臺灣大學醫學院檢驗醫學科
Type
journal article
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