高分子薄膜於外加電場下應用於血漿蛋白質分離的研究
Date Issued
2000-07-31
Date
2000-07-31
Author(s)
DOI
892314B002259
Abstract
Previous experiments have proved that
membranes have the possibility to separate of
globulins and albumin. From these
experiments, we found the pitfall causing the
lower filtration efficiency is due to the “cake”
formation on the membranes. In order to
improve this pitfall, we try to add an electric
field and cross-flow to the experiments. As
we know, the anode will attract the negativechanged
globulins with the cross-flow that
will prevent the obstruction of the
micropores. By the way, the cross-flow will
simulate the condition of cascade filtration by
its continuous flow. So, three parts will
compose the studies: 1) Identification of
membrane structures including surface and
cross-section, measuring size of the
micropores, contact angles and degree of
crystallization. 2) Experiments of protein
solutions filtered through membranes within
a cross-flow device under electric field. 3)
Experiments of plasma of different
composition filtered through membranes
under the same conditions of above. We
hope this simple cross-flow and electric field
design will improve the filtration efficacy
and let the membrane can be used clinically
in cascade or double filtration technique in
therapeutic plasmapheresis.
Subjects
protein separation
membrane
electric field
Publisher
臺北市：國立臺灣大學醫學院檢驗醫學科
Type
journal article
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