原發性肺癌CD44基因之表現與DNA之甲基化的關係(2/2)
Date Issued
2003-07-31
Date
2003-07-31
Author(s)
���R�R
DOI
902314B002288
Abstract
Methylation of the CD44 promoter at one or more CpG dinucleotides has been proposed
as being important in the control of CD44 expression. In our previous study we found
CD44 was down-regulated in patients with more advanced stages of pulmonary
adenocarcinoma. Therefore in this study we examined the methylation status of the 6
CpG sites in the promoter region upstream the CD44 gene translation initiation site by
genomic sequencing using differential base modification by sodium bisulfite. In 15 tumor
samples of the surgically resected pulmonary adenocarcinoma, we found there was no
consistent relationship between methylation status of any of these 6 CpG sites and the
expression of the CD44v6 protein as studied by immunohistochemical staining.
Publisher
臺北市：國立臺灣大學醫學院檢驗醫學科
Type
journal article
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