DFO經皮給藥的可行性研究
Date Issued
2003-07-31
Date
2003-07-31
Author(s)
DOI
912314B002170
Abstract
The goal of this study is to help thalassemia patients, who chronically require blood
transfusions to keep alive. However, such long-term transfusions can easily lead to a
build-up of trivalent iron and produce an iron overload condition. To treat iron overload,
the patients usually receive intravenous or subcutaneous deferoxamine mesylate (DFO)
regularly. But, because of the pain the patients may resist taking drug, so the effects of
treatment are not very good. Consequently, we hope to be able to change the method of
delivering DFO—we want to see if we can replace the injection method with
transdermal drug delivery. The preliminary goal of the study, therefore, is to assess the
feasibility of designing and fabricating a DFO patch using an adhesive dispersion-type
transdermal drug delivery system. It is hoped that it can let the drug pass through the
skin at a fixed rate of speed and reach the circulation system, from where it can spread
its therapeutic effect throughout the body. In this research, we choose the commercial
pressure sensitive adhesives to be the drug reservoirs and observe the release profile of
DFO in the adhesives in order to develop and design transdermal patchs.
Subjects
thalassemia
transdermal drug delivery system
Publisher
臺北市：國立臺灣大學醫學院檢驗醫學科
Type
journal article
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