DC 欄位 | 值 | 語言 |
dc.contributor.author | 林東燦 | zh-TW |
dc.creator | 林東燦 | zh_TW |
dc.date | 2003-07-31 | zh_TW |
dc.date.accessioned | 2006-07-26T04:53:49Z | en |
dc.date.accessioned | 2018-07-12T08:59:37Z | - |
dc.date.available | 2006-07-26T04:53:49Z | en |
dc.date.available | 2018-07-12T08:59:37Z | - |
dc.date.issued | 2003-07-31 | - |
dc.identifier | 912314B002170 | en |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/27340 | - |
dc.description.abstract | 海洋性貧血病人需長期接受輸血以維持生命,然而長期輸血容易導致病人體
內三價鐵離子含量過高而產生鐵中毒的現象,鐵中毒慣例上採用deferoxamine
mesylate(Desferal, DFO)連續式點滴或皮下注射以螯合治療,但病患容易因為疼痛
而產生排斥感,使治療效果不佳,所以我們希望能夠改變藥物劑型,企圖以經皮
給藥的方式來取代注射治療,本實驗的目的即是評估將DFO 製成貼劑貼在皮膚上
給藥的可行性,將選擇基質式經皮吸收系統,使DFO 能穿過皮膚,藉以設計DFO
貼片。此貼片希望能夠以一定傳送速率讓藥穿過皮膚到達循環系統,而達全身性
治療效果。本實驗係以商用感壓膠為基質,探討DFO 在其中的藥物釋放情形,以
開發為經皮吸收貼劑。 | zh_TW |
dc.description.abstract | The goal of this study is to help thalassemia patients, who chronically require blood
transfusions to keep alive. However, such long-term transfusions can easily lead to a
build-up of trivalent iron and produce an iron overload condition. To treat iron overload,
the patients usually receive intravenous or subcutaneous deferoxamine mesylate (DFO)
regularly. But, because of the pain the patients may resist taking drug, so the effects of
treatment are not very good. Consequently, we hope to be able to change the method of
delivering DFO—we want to see if we can replace the injection method with
transdermal drug delivery. The preliminary goal of the study, therefore, is to assess the
feasibility of designing and fabricating a DFO patch using an adhesive dispersion-type
transdermal drug delivery system. It is hoped that it can let the drug pass through the
skin at a fixed rate of speed and reach the circulation system, from where it can spread
its therapeutic effect throughout the body. In this research, we choose the commercial
pressure sensitive adhesives to be the drug reservoirs and observe the release profile of
DFO in the adhesives in order to develop and design transdermal patchs. | en |
dc.format | application/pdf | en |
dc.format.extent | 43217 bytes | en |
dc.format.mimetype | application/pdf | en |
dc.language | zh_TW | zh_TW |
dc.language.iso | zh_TW | zh_TW |
dc.publisher | 臺北市:國立臺灣大學醫學院檢驗醫學科 | zh_TW |
dc.rights | 國立臺灣大學醫學院檢驗醫學科 | zh_TW |
dc.subject | 海洋性貧血 | zh_TW |
dc.subject | Desferal | zh_TW |
dc.subject | 經皮給藥系統 | zh_TW |
dc.subject | thalassemia | en |
dc.subject | transdermal drug delivery system | en |
dc.title | DFO經皮給藥的可行性研究 | zh_TW |
dc.type | journal article | en |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/27340/1/912314B002170.pdf | - |
dc.coverage | 計畫年度:91;起迄日期:2002-08-01/2003-07-31 | zh_TW |
item.openairetype | journal article | - |
item.fulltext | with fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | open | - |
item.languageiso639-1 | zh_TW | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.orcid | 0000-0002-5773-3200 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系
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