https://scholars.lib.ntu.edu.tw/handle/123456789/202002
標題: | Human C-Reactive Protein (Crp) Gene 1059 G>C Polymorphism Is Associated with Plasma Crp Concentration in Patients Receiving Coronary Angiography | 作者: | DAI, DAO-FU FU-TIEN CHIANG JIUNN-LEE LIN CHI-LING CHEN CHANG, CHEE-JEN LING-PING LAI HSU, KWAN-LIH TSENG, CHUEN-DEN TSENG, YUNG-ZU JUEY-JEN HWANG |
關鍵字: | C-reactive protein;CRP;coronary artery disease;genetic polymorphism;myocardial infarction | 公開日期: | 五月-2007 | 卷: | 106 | 期: | 5 | 起(迄)頁: | 347 | 來源出版物: | JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION | 摘要: | Background/Purpose: Elevation of C-reactive protein (CRP) level is associated with increased risk of cardiovascular events. The 1059 G > C polymorphism in exon 2 of the CRP gene has been shown to affect plasma concentration of CRP. We want to elucidate the effect of this polymorphism on the development of coronary artery disease (CAD) among the Chinese population in Taiwan. Methods: We scrutinized 536 patients undergoing coronary angiography (365 patients with CAD and 171 controls with patent coronaries) and evaluated the association of CRP gene 1059 G > C polymorphism with CAD. Genotyping of the polymorphism was performed by polymerase chain reaction and MaeIII restriction enzyme digestion. Results: The CC genotype was associated with lower plasma CRP concentration (GG, 6.5±5.8, GC, 3.3 ± 4.4; CC, 2.3±3.1 mg/L; p= 0.02). Subjects with CAD or myocardial infarction (MI) had significantly higher plasma CRP concentration than that in controls (CAD vs. controls, 8.9±18.9 vs. 3.3±7.2 mg/L; p<0.001), while patients with MI showed higher CRP when compared to those with chronic stable angina (13.5 ±22.9 vs. 5.2±14.1 mg/L; p [removed]C polymorphism is associated with plasma CRP concentration among Chinese in Taiwan receiving coronary angiography. © 2007 Elsevier & Formosan Medical Association. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/89450 https://www.scopus.com/record/display.uri?eid=2-s2.0-34250616292&doi=10.1016%2fS0929-6646%2809%2960319-3&origin=inward&txGid=be3296dc06621f260f1544c05b2a9afe |
ISSN: | 09296646 | DOI: | 10.1016/S0929-6646(09)60319-3 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。