The mechanism(s) of effect of phytoestrogens on the cell proliferation and inflammatory factors release
Date Issued
2003-07-31
Date
2003-07-31
Author(s)
蔡克嵩
DOI
912314B002343
Abstract
Phytoestrogens are naturally occurring plant compounds that are present primarily in
soybeans as isoflavones and in flaxseed as lignans. These plant chemicals display
estrogen-like activity because of their structural similarity to human estrogens and
exhibit high affinity binding for the estrogen receptor beta. Few, if any, studies have
been made on the impact of these phytoestrogens on the immune system. The aims of
this study, therefore, are twofold. The first goal is to verify the effects of phytoestrogens
on the modulation of the cell proliferation and release of inflammatory mediators in
macrophages and glomerular mesangial cell. The role of estrogen receptor in these
responses is also investigated. Second, we try to investigate the possible molecular
mechanism(s) involving in the effect of phytoestrogens on the macrophages and
glomerular mesangial cell. In this year’s works, we found that low concentration range
(3-100 nM) of phytoestrogens (-sitosterol, resveratrol and genistein) were capable of
increasing cell proliferation and inducing the cyclooxygenase-2 protein and mRNA
expression in macrophage and glomerular mesangial cell line, which could be partially
inhibited by selective estrogen receptor antagonist ICI182780. The expression of
COX-1 protein did not affected by these phytoestrogens. These results imply that there
are some influences by phytoestrogens in immune system.
Subjects
phytoestrogens
macrophages
mesangial cells
cell proliferation
cyclooxygenase-2
Publisher
臺北市：國立臺灣大學醫學院檢驗醫學科
Type
journal article
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