https://scholars.lib.ntu.edu.tw/handle/123456789/202107
標題: | Tumour-Infiltrating Lymphocytes in Non-Small Cell Lung Cancer Are Activated T Lymphocytes | 作者: | KUO, SOW-HSONG CHANG, DUN-BING LEE, YA-TING LEE, YUNG-CHIE |
公開日期: | 1998 | 卷: | v.5 | 期: | n.1 | 起(迄)頁: | 55-59 | 來源出版物: | RESPIROLOGY | 摘要: | This study was carried out in order to investigate the local immune reaction of tumour-infiltrating lymphocytes (TILs) in the primary tumours of non-small cell lung carcinomas. Thirty non-small cell lung cancer ( NSCLC) patients were included. The tumour tissue was taken at thoracotomy and monocellular suspension of the tumour was obtained by mechanical disaggregation. Dual-coloured flow cytometric analysis of TILs and their corresponding peripheral blood lymphocytes (PBLs) was performed. Tumour- infiltrating lymphocytes contained significantly higher proportions of CD 3(+) T lymphocytes and CD8(+) T lymphocytes than the corresponding PBLs ( 82.0%+/-13.9% vs 66.3%+/-10.6% for CD3, P<0.001; 39.0%+/-18.4% vs 26.4%+/- 5.2% for CD8, P<0.001). Tumour-infiltrating lymphocytes contained significantly higher proportions of activated memory lymphocytes than PBLs did (9.8%+/-8.6% vs 1.3%+/-1.5% for CD25, P<0.001; 40.5%+/- 30.2% vs 10.2 %+/-14.8% for CD71, P<0.001; 75.5%+/-11.9% vs 28.6%+/-9.8% for HLA-DR, P<0 .001). These findings were also found in both CD4(+) TILs and CD8(+) TILs. The TILs of NSCLC contained higher proportions of T lymphocytes and CD8(+ ) lymphocytes than their corresponding peripheral bloods. The proportions of activated memory lymphocytes were also significantly higher in the TILs , both in CD4(+) TILs and CD 8(+) TILs, than the corresponding PBLs. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/94609 |
顯示於: | 醫學系 |
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